中华烧伤杂志
中華燒傷雜誌
중화소상잡지
16
2014年
3期
261-264
,共4页
烧伤%免疫%炎症小体%炎症反应
燒傷%免疫%炎癥小體%炎癥反應
소상%면역%염증소체%염증반응
Burns%Immunity%Inflammasome%Inflammatory response
Inflammasomes are large muhi-protein complexes that serve as a platform for caspase-1 activation,and this process induces subsequent maturation and secretion of the proinflammatory cytokines IL-1β and IL-18,as well as pyroptosis.As an important component of the innate immune system,early activation of inflammasomes in a variety of immune cell subsets can mediate inflammatory response and immunological conditions after burn injury.Here,we review the current knowledge of inflammasomes and its role in immunological and inflammatory response at the early stage of burn injury.
