CAJ | 학술논문

目的通过随机对照研究分析早期口服双歧杆菌三联活菌散对住院早产儿喂养不耐受的影响，评估其有效性及安全性。方法2012年1月～2013年1月入住新生儿科的早产儿根据入选标准纳入研究，根据是否口服双歧杆菌三联活菌散随机分为实验组（生后24h内口服或鼻饲双歧杆菌三联活菌散0.5g/次，2次/d）和对照组。两组均开始早期微量喂养，比较两组早产儿出生2周内一般情况、喂养相关指标及其他并发症情况。结果符合入组标准完成实验的早产儿共133例，其中实验组62例，对照组71例。两组出生体重、胎龄、头围、Apgar评分及开始肠内喂养的时间差异均无统计学意义（P＞0.05）。实验组喂养不耐受的发生率为17.7%（11例），对照组为36.6%（26例），两组有显著差异（χ2=5.874，P=0.0154），两组胎便排完日龄、体重增长及达全奶量喂养的日龄有显著差异（P均＜0.05）。结论早期口服双歧杆菌三联活菌可以降低早产儿喂养不耐受的发生率，促进胎便的排出，提前达到全肠道喂养的时间。并且没有增加NEC的风险。
목적통과수궤대조연구분석조기구복쌍기간균삼련활균산대주원조산인위양불내수적영향，평고기유효성급안전성。방법2012년1월～2013년1월입주신생인과적조산인근거입선표준납입연구，근거시부구복쌍기간균삼련활균산수궤분위실험조（생후24h내구복혹비사쌍기간균삼련활균산0.5g/차，2차/d）화대조조。량조균개시조기미량위양，비교량조조산인출생2주내일반정황、위양상관지표급기타병발증정황。결과부합입조표준완성실험적조산인공133례，기중실험조62례，대조조71례。량조출생체중、태령、두위、Apgar평분급개시장내위양적시간차이균무통계학의의（P＞0.05）。실험조위양불내수적발생솔위17.7%（11례），대조조위36.6%（26례），량조유현저차이（χ2=5.874，P=0.0154），량조태편배완일령、체중증장급체전내량위양적일령유현저차이（P균＜0.05）。결론조기구복쌍기간균삼련활균가이강저조산인위양불내수적발생솔，촉진태편적배출，제전체도전장도위양적시간。병차몰유증가NEC적풍험。
Objective To evaluate the effectiveness and possible side effects of early oral bulk triple viable biifdobacterium for treatment of feeding intolerance(FI) in preterm infants.Methods 133 preterm infants admitted in neonate department in our hospital from January 2012 to January 2013.The patients were assigned into 2 groups randomly:treatment group(oral bulk triple viable bifidobacterium 0.5g every 12 hours) and control group,not using any drugs influencing gastrointesinal dynamics.Indicators of feeding condition were compared.Results 133 patients were included.62 in treatment group and 71 in control group.The weight growth were signiifcantly greater in the treatment group than the control group.The rate of FI,the time of discharge of meconium and the time of establishing total feeding were signiifcantly shorter in the treatment group than the control group,and no obvious side effects and NEC were found.Conclusions Early oral bulk triple viable biifdobacterium can decrease the rate of FI in preterm infants,promote discharge of meconium and weight growth.No obvious side effects and NEC were found.