CAJ | 학술논문

目的探讨重组组织型纤溶酶原激活剂（rt-PA）静脉溶栓治疗心源性脑栓塞（CCE）的疗效及安全性。方法符合入选标准的患者，溶栓组25例，对照组25例。发病3h内行rt-PA（0.9mg/kg）静脉溶栓治疗，评定治疗后24h、7d NIHSS评分，90d Barthel指数评分。观察颅内出血转化、脑水肿发生情况。结果溶栓后7d时NIHSS评分显著改善（P＜0.05）。溶栓组90d生活质量评分高于对照组。溶栓组症状性脑出血发生率与对照组无差异。溶栓组严重脑水肿发生率低于对照组。结论3h内对心源性脑栓塞患者实施rt-PA静脉溶栓治疗安全有效。
목적탐토중조조직형섬용매원격활제（rt-PA）정맥용전치료심원성뇌전새（CCE）적료효급안전성。방법부합입선표준적환자，용전조25례，대조조25례。발병3h내행rt-PA（0.9mg/kg）정맥용전치료，평정치료후24h、7d NIHSS평분，90d Barthel지수평분。관찰로내출혈전화、뇌수종발생정황。결과용전후7d시NIHSS평분현저개선（P＜0.05）。용전조90d생활질량평분고우대조조。용전조증상성뇌출혈발생솔여대조조무차이。용전조엄중뇌수종발생솔저우대조조。결론3h내대심원성뇌전새환자실시rt-PA정맥용전치료안전유효。
Objective To investigate the safety and efifcacy of intravenous thrombolysis with recombinant tissue-type plasminogen activator(rt-PA) in the treatment of acute cardiogenic cerebral embolism(CCE).Methods 25 cases were included in the thrombolysis group,and 25 cases in the control group.In the thrombolytsis group,the patients within an onset within 3 hours were given rt-PA(0.9mg/kg) for intravenouss thrombolytic therapy. The NIHSS scores were used before thrombolysis and at 24h,7d.Barthel Index(BI) were used to evaluate the neurological functions 90 days after receiving rt-PA.The occurrence of symptomatic intracerebral hemorrhage of cerebral edema was recorded.Results The NIHSS scores were improved at 7d(P<0.05).BI score of thrombolysis group was higher than that of control group at 90d.There was no significant difference between thrombolysis group and control group in the incidence of symptomatic intracerebral hemorrhage.The occurrence of severe brain edema in thrombolysis group was lower than that in control group.Conclusions It could be safe and efifcient for patients with CCE to receive the intravenous thrombolysis with rt-PA within 3 hours of the onset.