CAJ | 학술논문

目的研究脑毒清颗粒对脑缺血再灌注大鼠ICAM-1及hs-CRP的影响。方法SD雄性大鼠随机分为正常组、假手术组、模型组和脑毒清组，采用线栓法制备大鼠大脑中动脉栓塞（MCAO）模型，2h后抽取栓线对大鼠进行脑缺血再灌注，分别取12h、24h、48h，3个时间点观组察脑毒清颗粒对脑缺血再灌注大鼠神经症状、hs-CRP及梗死区脑组织ICAM-1蛋白含量的影响。结果在不同的时间点，脑毒清组大鼠的神经症状评分、hs-CRP及ICAM-1含量与模型组对比均有显著差异（P＜0.05）。结论脑毒清颗粒可以抑制脑缺血再灌注大鼠ICAM-1表达，血清hs-CRP升高，在防治脑缺血再灌注损伤过程中有一定作用。
목적연구뇌독청과립대뇌결혈재관주대서ICAM-1급hs-CRP적영향。방법SD웅성대서수궤분위정상조、가수술조、모형조화뇌독청조，채용선전법제비대서대뇌중동맥전새（MCAO）모형，2h후추취전선대대서진행뇌결혈재관주，분별취12h、24h、48h，3개시간점관조찰뇌독청과립대뇌결혈재관주대서신경증상、hs-CRP급경사구뇌조직ICAM-1단백함량적영향。결과재불동적시간점，뇌독청조대서적신경증상평분、hs-CRP급ICAM-1함량여모형조대비균유현저차이（P＜0.05）。결론뇌독청과립가이억제뇌결혈재관주대서ICAM-1표체，혈청hs-CRP승고，재방치뇌결혈재관주손상과정중유일정작용。
Objective To investigate the effects of Naoduqing on ICAM-1 and hs-CRP in rats with cerebral ischemia-reperfusion injury.Methods SD rats were randomly divided into normal group,sham operated group,model group and treatment group.We measured the content of ICAM-1 and hs-CRP,examining the neurological function,at 12h,24h 48h after successful modeling.Result All the treatment groups at different time point decreased the volume of ICAM-1 and hs-CRP.Compared with the model group,the level of ICAM-1 and hs-CRP was decreased and signiifcantly(P<0.05).Conclusion Naoduqing can regulate down the expression of ICAM-1 and hs-CRP.Naoduqing has a protective effect against the impairment of cerebral ischemia-reperfusion injury.