CAJ | 학술논문

目的：观察骨肉瘤中GRIM-19与STAT3的表达情况，探讨二者与骨肉瘤临床病理特征的关系及骨肉瘤二者表达的相关性。方法：采用免疫组织化学染色SP法检测35例骨肉瘤和14例骨软骨瘤GRIM-19与STAT3的表达情况。结果：骨肉瘤中STAT3的阳性表达率明显高于骨软骨瘤，GRIM-19的阳性表达率明显低于骨软骨瘤，差异均具有统计学意义(P＜0.01)；骨肉瘤中STAT3表达与Enneking分期、肺转移有关，GRIM-19表达与Enneking分期有关(P＜0.05)；骨肉瘤中STAT3表达与GRIM-19呈负相关(P＜0.05)。结论：骨肉瘤组织中存在STAT3高表达和GRIM-19低表达共存现象，二者共同作用可能与骨肉瘤的发生、发展密切相关。
목적：관찰골육류중GRIM-19여STAT3적표체정황，탐토이자여골육류림상병리특정적관계급골육류이자표체적상관성。방법：채용면역조직화학염색SP법검측35례골육류화14례골연골류GRIM-19여STAT3적표체정황。결과：골육류중STAT3적양성표체솔명현고우골연골류，GRIM-19적양성표체솔명현저우골연골류，차이균구유통계학의의(P＜0.01)；골육류중STAT3표체여Enneking분기、폐전이유관，GRIM-19표체여Enneking분기유관(P＜0.05)；골육류중STAT3표체여GRIM-19정부상관(P＜0.05)。결론：골육류조직중존재STAT3고표체화GRIM-19저표체공존현상，이자공동작용가능여골육류적발생、발전밀절상관。
Objective:To investigate the relationships between gene associated with retinoid-interferon-induced mortality-19 (GRIM-19), signal transducers and activators of transcription 3 (STAT3) and clinical pathological characteristics of osteosarcoma, and their correlations in osteosarcoma by observing the expression of GRIM-19 and STAT3 in osteosarcoma. Methods:SP immunohistochemical staining was used to detect the expression of GRIM-19 and STAT3 in 35 cases osteosarcoma and 14 cases osteochondroma. Results:The positive expression rate of STAT3 in osteosarcoma was obviously higher than that in osteochondroma, while the positive expression rate of GRIM-19 was obviously lower in osteosarcoma compared with osteochondroma (P<0.01). In osteosarcoma, the expression of STAT3 was associated with Enneking stage and pulmonary metastasis; the expression of GRIM-19 was associated with Enneking stage (P<0.05). In osteosarcoma, the expression of STAT3 was negatively correlated with expression of GRIM-19 (P<0.05). Conclusions:High expression of STAT3 and low expression of GRIM-19 coexist in osteosarcoma, which play important role in development of osteosarcoma.