CAJ | 학술논문

介绍了一种盐酸文拉法辛缓释胶囊的制备工艺条件，考察了辅料的选择、制粒粒径、助流剂、辅料的配比以及溶出介质对盐酸文拉法辛缓释胶囊体外溶出曲线的影响。结果表明，当羟丙甲基纤维素（HPMC）为100mg，甲基纤维素（MC）为25mg，制粒目数为16目，微粉硅胶质量分数为2．5％，以ZpH=6．8的磷酸盐缓冲溶液作为溶出介质时，制备的胶囊具有良好的缓释性。
개소료일충염산문랍법신완석효낭적제비공예조건，고찰료보료적선택、제립립경、조류제、보료적배비이급용출개질대염산문랍법신완석효낭체외용출곡선적영향。결과표명，당간병갑기섬유소（HPMC）위100mg，갑기섬유소（MC）위25mg，제립목수위16목，미분규효질량분수위2．5％，이ZpH=6．8적린산염완충용액작위용출개질시，제비적효낭구유량호적완석성。
Abstraet. The process technology for the preparation of venlafaxine hydrochloride sustained-release capsules was introduced. The influences of factors including different excipients, dosage of excipients, mesh number of medicinal sieve, dosage of glidant and dissolution medium upon the in vitro dissolution curves of venlafaxine hydrochloride capsules were investigated. The optimal prescription (dosage of HPMC and MC as well as the glidant mass fraction were 100 mg,25 mg and 2: 5% ,respectively. The mesh number was 16) accorded with the request of the sustained-release experiment design while phosphate buffered solution(pH = 6.8)was employed as dissolution medium.