CAJ | 학술논문

　　目的研究慢性乙型肝炎患者肝功能指标与肝硬度值之间的关系。方法研究对象包括35例慢性乙型肝炎患者，间隔1～33周分别检测瞬时弹性探测仪（Fibro-Scan）肝硬度值，及血清ALT、AST、GGT、ALB、GLO和TBIL等。分析两次肝功能指标值、年龄等与对应肝硬度值的相关性及两次肝功能指标变化值、两次检测间隔时间等与肝硬度变化值之间的相关性。以肝硬度变化值为因变量，以肝功能指标变化值及年龄和两次检测间隔周数等为自变量，进行多元回归分析。结果两次检测的GGT、ALB、TBIL与DBIL水平与肝硬度值之间均存在一定的相关性；年龄、两次检测AST、GGT、GLO、TBIL与DBIL变化值与肝硬度变化值之间，存在一定的相关性（r=0.380、0.503、0.536、0.369、0.341、0.497；P<0.05）。两次检测间隔时间与肝硬度变化值之间没有明显的相关性（P>0.05）。多元回归分析结果：肝硬度变化值=0.4982× GLO变化值+0.4621× DBIL变化值（F=15.108，P<0.001）。结论炎症程度影响肝脏硬度值，但难以通过AST等校正Fibroscan测量值的方式来准确地评估肝纤维化程度。
　　목적연구만성을형간염환자간공능지표여간경도치지간적관계。방법연구대상포괄35례만성을형간염환자，간격1～33주분별검측순시탄성탐측의（Fibro-Scan）간경도치，급혈청ALT、AST、GGT、ALB、GLO화TBIL등。분석량차간공능지표치、년령등여대응간경도치적상관성급량차간공능지표변화치、량차검측간격시간등여간경도변화치지간적상관성。이간경도변화치위인변량，이간공능지표변화치급년령화량차검측간격주수등위자변량，진행다원회귀분석。결과량차검측적GGT、ALB、TBIL여DBIL수평여간경도치지간균존재일정적상관성；년령、량차검측AST、GGT、GLO、TBIL여DBIL변화치여간경도변화치지간，존재일정적상관성（r=0.380、0.503、0.536、0.369、0.341、0.497；P<0.05）。량차검측간격시간여간경도변화치지간몰유명현적상관성（P>0.05）。다원회귀분석결과：간경도변화치=0.4982× GLO변화치+0.4621× DBIL변화치（F=15.108，P<0.001）。결론염증정도영향간장경도치，단난이통과AST등교정Fibroscan측량치적방식래준학지평고간섬유화정도。
Objective To study the correlation between liver functions and liver stiffness in patients with chronic hepatitis B (CHB). Methods Thirty-five patients with CHB were enrolled. The liver stiffness values (measured by Fibroscan), serum ALT, AST, GGT, ALB, GLO and TBIL were detected twice during an interval of 1-33 weeks. The relationship between values of liver function or age and liver stiffness values, between the changes of twice liver function values or the times of detection intervals and the changes of liver stiffness were investigated. Multivariate regression analysis was carried out, with the liver stiffness changes as the dependent variable, the changes of ALT, AST, GGT, ALB, GLO, TBIL, DBIL, age and the times of detection interval as independent variables. Result The GGT, ALB, TBIL and DBIL levels were correlated with liver stiffness;Age, and the changes of AST, GGT, GLO, TBIL and DBIL were correlated with the changes of liver stiffness (r=0.380, 0.503, 0.536, 0.369, 0.341, 0.497;P<0.05). The times of detection interval and the changes of liver stiffness had shown no significant correlation (P>0.05). Multivariate regression analysis showed: liver stiff-ness value changes=0.4982 × GLO changes+0.4621 × DBIL changes (F=15.108, P<0.001). Conclusion The degree of inflammation affected the liver stiffness values. However, it is difficult to accurately assess the degree of liver fibrosis by Fibroscan test by corrected AST levels.