CAJ | 학술논문

目的观察外用清热利湿中药（自拟中药止痒平肤液）治疗表皮生长因子受体拮抗剂（EGFRIs）相关痤疮样皮疹的疗效，并评价药物的安全性。方法选择经病理学诊断明确的、应用EGFRIs后出现相关痤疮样皮疹、中医证型为“风热型”及“湿热型”的恶性肿瘤患者120例，随机分为治疗组80例和对照组40例。治疗组外用自拟中药止痒平肤液，对照组外用红霉素软膏，连续应用14 d。观察治疗前后2组患者皮疹变化以及血常规、肝、肾功能等安全性指标。结果在痤疮样皮疹改善方面治疗组有效57例，稳定23例；对照组有效7例，稳定33例；在瘙痒程度改善上治疗组有效45例，稳定35例；对照组有效3例，稳定37例。经SPSS 7.0统计软件分析得出P值均<0.05，具有统计学差异，中药疗效优于红霉素软膏。血常规及肝、肾功能检验均未见明显血液学毒性。未出现与外用药物相关的不良反应。结论自拟中药止痒平肤液用于改善EGFRIs相关痤疮样皮疹及瘙痒效果显著，且无明显不良反应。
목적관찰외용청열리습중약（자의중약지양평부액）치료표피생장인자수체길항제（EGFRIs）상관좌창양피진적료효，병평개약물적안전성。방법선택경병이학진단명학적、응용EGFRIs후출현상관좌창양피진、중의증형위“풍열형”급“습열형”적악성종류환자120례，수궤분위치료조80례화대조조40례。치료조외용자의중약지양평부액，대조조외용홍매소연고，련속응용14 d。관찰치료전후2조환자피진변화이급혈상규、간、신공능등안전성지표。결과재좌창양피진개선방면치료조유효57례，은정23례；대조조유효7례，은정33례；재소양정도개선상치료조유효45례，은정35례；대조조유효3례，은정37례。경SPSS 7.0통계연건분석득출P치균<0.05，구유통계학차이，중약료효우우홍매소연고。혈상규급간、신공능검험균미견명현혈액학독성。미출현여외용약물상관적불량반응。결론자의중약지양평부액용우개선EGFRIs상관좌창양피진급소양효과현저，차무명현불량반응。
Objective To observe the curative effect of external Chinese medicinal with actions of clearing heat and draining dampness (self-made Zhiyang Pingfu Ye) on epidermal growth factor receptor inhibitors (EGFRIs)-related acne rash, and review the safety. Methods The patients (n=120) with malignant cancer suffering from acne rash after using EGFRIs diagnosed pathologically (syndrome types of wind heat or dampness heat) were chosen and then randomly divided into treatment group (n=80) and control group (n=40). The treatment group was treated externally with self-made Zhiyang Pingfu Ye, and control group, with erythromycin ointment all for 14 days. The changes of acne rash and safety indexes of routine blood test and liver and kidney functions were observed in two groups before and after treatment. Results In the aspect of abating acne rash, there were 57 cases with curative effect and 23 being stable in treatment group, and 7 with curative effect and 33 being stable in control group. In the aspect of relieving pruritus, there were 45 cases with curative effect and 35 being stable in treatment group, and 3 with curative effect and 37 being stable in control group. The analysis of SPSS 7.0 software showed that all P<0.05 with statistical significance. The curative effect of Chinese medicinal was better than that of erythromycin ointment. There were no significant hematological toxicity and adverse reactions observed in the tests of routine blood test and liver and kidney functions. Conclusion Self-made Zhiyang Pingfu Ye has significant curative effect on EGFRIs-related acne rash in abating acne rash and relieving pruritus and has no adverse reactions.