CAJ | 학술논문

目的观察华蟾素胸腹腔灌注治疗恶性胸腹水的临床疗效与安全性，初步探讨其机制。方法共纳入符合标准的恶性胸腹水患者30例，留置胸腹腔引流管，尽量排尽胸腹水后给予生理盐水250 mL+华蟾素注射液40 mL胸腹腔灌注。每周3次，2周为1个疗程。1个疗程后根据胸腹水量、肿瘤标记物（TM）、红细胞（RBC）及患者症状进行疗效评价。结果总有效率46.67%；75.00%（12/16）肉眼血性胸腹水患者治疗后红色明显变浅；大部分患者胸腹水中TM、RBC水平明显下降。结论华蟾素胸腹腔灌注治疗局部辨证为湿热毒证的恶性胸腹水具有一定疗效。
목적관찰화섬소흉복강관주치료악성흉복수적림상료효여안전성，초보탐토기궤제。방법공납입부합표준적악성흉복수환자30례，류치흉복강인류관，진량배진흉복수후급여생리염수250 mL+화섬소주사액40 mL흉복강관주。매주3차，2주위1개료정。1개료정후근거흉복수량、종류표기물（TM）、홍세포（RBC）급환자증상진행료효평개。결과총유효솔46.67%；75.00%（12/16）육안혈성흉복수환자치료후홍색명현변천；대부분환자흉복수중TM、RBC수평명현하강。결론화섬소흉복강관주치료국부변증위습열독증적악성흉복수구유일정료효。
Objective To observe the curative effect and safety of Huachansu Injection poured into thorax and abdomen in the treatment of malignant hydrothorax and ascite, and discuss the mechanism initially. Methods The patients with malignant hydrothorax and ascite (n=30) were chosen and given the perfusion treatment in thorax and abdomen three times a week (250 mL normal saline and 40 mL Huachansu Injection) after draining pleuroperitoneal fluid. One therapeutic course was two weeks. After one therapeutic course, the review on curative effect was conducted according to quantity of pleuroperitoneal fluid, tumor marker (TM), RBC count and symptoms. Results The total effective rate was 46.67%. The red color became lighter in 75.00% (12/16) patients with bloody hydrothorax and ascite by naked eye. The levels of TM and RBC count decreased significantly in the most of patients. Conclusion The perfusion treatment of Huachansu Injection has certain curative effect on malignant hydrothorax and ascite diagnosed as syndrome of dampness heat toxin.