北京中医药大学学报（中医临床版）
北京中醫藥大學學報（中醫臨床版）
북경중의약대학학보（중의림상판）
JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE(CLINICAL MEDICINE)
2013年
4期
1-4,10
,共5页
中风%痰热腑实%脑肠轴
中風%痰熱腑實%腦腸軸
중풍%담열부실%뇌장축
stroke%phlegm heat and bowel excess%brain-gut axis
综述中风病肠道功能紊乱的发病情况及危害，胃肠道功能紊乱脑肠轴机制，中风病痰热腑实证的发生及中药治疗效应机制。目前研究普遍认为：卒中后脑肠肽应激性升高，其升高水平与卒中严重程度呈正相关。痰热腑实证患者胃动素水平较其他证候明显升高。迄今为止对化痰通腑法治疗中风病痰热腑实证的疗效机制主要从调节脑肠轴、抑制炎性反应、改善血液流变学3个方面进行了研究。
綜述中風病腸道功能紊亂的髮病情況及危害，胃腸道功能紊亂腦腸軸機製，中風病痰熱腑實證的髮生及中藥治療效應機製。目前研究普遍認為：卒中後腦腸肽應激性升高，其升高水平與卒中嚴重程度呈正相關。痰熱腑實證患者胃動素水平較其他證候明顯升高。迄今為止對化痰通腑法治療中風病痰熱腑實證的療效機製主要從調節腦腸軸、抑製炎性反應、改善血液流變學3箇方麵進行瞭研究。
종술중풍병장도공능문란적발병정황급위해，위장도공능문란뇌장축궤제，중풍병담열부실증적발생급중약치료효응궤제。목전연구보편인위：졸중후뇌장태응격성승고，기승고수평여졸중엄중정도정정상관。담열부실증환자위동소수평교기타증후명현승고。흘금위지대화담통부법치료중풍병담열부실증적료효궤제주요종조절뇌장축、억제염성반응、개선혈액류변학3개방면진행료연구。
The authors summed up the onset and damage of the disorder of intestinal function after stroke, and discussed the mechanism from the changes of brain-gut axis. The study results showed that after stroke the stress of brain-gut peptide increased and correlated to stroke degree. The level of motilin was significantly higher in the patients with syndrome of phlegm heat and bowel excess than in those with other syndromes. The effective mechanism of therapy of resolving phlegm and relaxing bowels was summarized from regulating brain-gut axis, inhibiting inflammatory reaction and improving hemorrheology.
