医学研究与教育
醫學研究與教育
의학연구여교육
MEDICAL RESEARCH AND EDUCATION
2013年
4期
75-79
,共5页
S100B蛋白%孕龄%胎儿生长受限%新生儿缺血缺氧性脑病
S100B蛋白%孕齡%胎兒生長受限%新生兒缺血缺氧性腦病
S100B단백%잉령%태인생장수한%신생인결혈결양성뇌병
S100B protein%gestational age%fetal growth restriction%neonatal hypoxic ischemic encephalopathy
国内外学者确定围产儿脑损伤的基本诊断步骤主要是建立在临床表现、大脑超声、动态脑电图监测、脑脊液检查、脑部CT、MRI、及多普勒的基础之上，但这些方法具有不便利性、复杂性、动态监测性差、医疗费用高、发现脑损伤时间较晚等缺点，这就导致临床上不能及早诊断及采取治疗措施。而脑自身成份S100B作为神经系统细胞损伤的直接预测因子，具有敏感性高、便于操作、重复性好、可以进行动态监测等优点，同时还可以对脑损伤程度进行定量观察。现就S100B蛋白的生物学特性、检测及其在围产医学中的应用进行综述。
國內外學者確定圍產兒腦損傷的基本診斷步驟主要是建立在臨床錶現、大腦超聲、動態腦電圖鑑測、腦脊液檢查、腦部CT、MRI、及多普勒的基礎之上，但這些方法具有不便利性、複雜性、動態鑑測性差、醫療費用高、髮現腦損傷時間較晚等缺點，這就導緻臨床上不能及早診斷及採取治療措施。而腦自身成份S100B作為神經繫統細胞損傷的直接預測因子，具有敏感性高、便于操作、重複性好、可以進行動態鑑測等優點，同時還可以對腦損傷程度進行定量觀察。現就S100B蛋白的生物學特性、檢測及其在圍產醫學中的應用進行綜述。
국내외학자학정위산인뇌손상적기본진단보취주요시건립재림상표현、대뇌초성、동태뇌전도감측、뇌척액검사、뇌부CT、MRI、급다보륵적기출지상，단저사방법구유불편리성、복잡성、동태감측성차、의료비용고、발현뇌손상시간교만등결점，저취도치림상상불능급조진단급채취치료조시。이뇌자신성빈S100B작위신경계통세포손상적직접예측인자，구유민감성고、편우조작、중복성호、가이진행동태감측등우점，동시환가이대뇌손상정도진행정량관찰。현취S100B단백적생물학특성、검측급기재위산의학중적응용진행종술。
The fundamental diagnostic procedures of perinatal brain injury determined by domestic and foreign scholars are based on the clinical manifestations, cerebral ultrasound, dynamic electroencephalogram monitoring, cerebrospinal lfuid examination, cerebral CT, MRI and doppler ultrasound. However, these methods mentioned above have some shortcomings, such as inconvenience, complexity, poor dynamic monitoring, high medical cost, late for ifnding the brain injury, et.al, which often result in slow diagnosis and treatment. However, the S100B protein coming from the brain itself, as the direct predictive factors of cell injury in nervous system, have some advantages, such as high sensitivity, easy operation, good reproducibility, easy dynamic monitoring, et.al. Furthermore, it can quantitatively observe the brain injury. The paper introduces the biological characteristics, detection methods of S100B protein and the recent developments of its applications in perinatal medicine.
