CAJ | 학술논문

目的：探讨检测血清抗内耳组织抗体及抗人Ⅱ型胶原抗体对自身免疫病感音神经性聋的临床意义。方法：选取49例自身免疫病住院患者分为耳聋组(A组)和非耳聋组(B组),同期20例健康志愿者为对照组(C组)。间接免疫荧光法检测血清抗内耳组织抗体,ELISA法检测血清抗人Ⅱ型胶原抗体水平。比较各组临床特征及两种自身抗体检测的结果。结果：A组20例(32耳)占免疫病组患者的40.8%(患耳占32.6%)。血清抗内耳组织抗体IgM、IgG阳性率：A组与B组比较无统计学差异(P>0.05),IgM A组B组均高于C组(0%)(P<0.01),IgG A组B组较C组增高,无统计学意义(P>0.05)。血清抗人Ⅱ型胶原抗体水平A组显著高于B组(P<0.01),且均高于C组(P<0.01)。结论：自身免疫病患者中血清抗内耳组织抗体对感音神经性聋的发生无提示意义,血清抗人Ⅱ型胶原抗体水平增高有临床意义。
목적：탐토검측혈청항내이조직항체급항인Ⅱ형효원항체대자신면역병감음신경성롱적림상의의。방법：선취49례자신면역병주원환자분위이롱조(A조)화비이롱조(B조),동기20례건강지원자위대조조(C조)。간접면역형광법검측혈청항내이조직항체,ELISA법검측혈청항인Ⅱ형효원항체수평。비교각조림상특정급량충자신항체검측적결과。결과：A조20례(32이)점면역병조환자적40.8%(환이점32.6%)。혈청항내이조직항체IgM、IgG양성솔：A조여B조비교무통계학차이(P>0.05),IgM A조B조균고우C조(0%)(P<0.01),IgG A조B조교C조증고,무통계학의의(P>0.05)。혈청항인Ⅱ형효원항체수평A조현저고우B조(P<0.01),차균고우C조(P<0.01)。결론：자신면역병환자중혈청항내이조직항체대감음신경성롱적발생무제시의의,혈청항인Ⅱ형효원항체수평증고유림상의의。
Objective: To investigate the detection of clinical significance of serum anti-inner ear tissue antibody and anti-human type II collagen antibody in autoimmune disease with sensorineural deafness.Methods:Select 49 cases of autoimmune disease in hospitalized patients divided into deafness group (group A) and non-deafness group (group B), the same period in 20 healthy volunteers as a control group (group C).The serum anti-inner ear tissue antibodies were detected with indirect immunofluorescence,and the serum level of anti-human collagen type II antibody was measured with ELISA.Some clinical features of the three groups and the results of these autoantibodies were compared.Results:A group of 20 cases (32 ears) accounted for 40.8%of the patients immune disease group(suffered ear accounted for 32.6%).Serum anti-inner ear tissue antibody IgM, IgG positive rate: group A and group B showed no significant difference(P>0.05),IgM in group A and group B was higher than group C (0%) (P<0.01), IgG in group A and group B was more increased than group C, was not statistically significant(P>0.05). The serum anti-human collagen type II antibody levels in group A was significantly higher than in group B (P<0.01),and the levels of both groups also respectively higher than that of group C(P<0.01).Conclusion:There was not obvious relationship between the presence of serum anti-inner ear tissue antibodies and the occurrence of sensorineural deafness in patients with systemic autoimmune diseases;the increased serum level of anti-human collagen type II antibody is associated with the occurrence of sensorineural deafness and has clinical significance.