CAJ | 학술논문

[目的]探讨阿托伐他汀联合替米沙坦对2型糖尿病肾病（DN）患者血清转化生长因子-β1（TGF-β1）和结缔组织生长因子（CTGF）的影响。[方法]将80例DN患者随机分为观察组和对照组各40例，对照组给予替米沙坦治疗，观察组给予阿托伐他汀联合替米沙坦治疗，12周后分析比较两组患者的平均动脉血压（MAP）、血总胆固醇（TC）、血甘油三脂（TG）、血肌酐（SCr）、血尿素氮（BUN）、尿白蛋白排泄率（UAER）及血清TGF-β1、CTGF水平。[结果]两组患者的MAP、SCr、BUN、UAER、TGF-β1及CTGF水平均较治疗前降低，差异有统计学意义（ P＜0．05）；观察组TC、TG水平也较治疗前明显下降（ P＜0．05），且其TC、TG、SCr、BUN、UAER及TGF-β1水平改善优于对照组（ P＜0．05）。[结论]阿托伐他汀联合替米沙坦治疗DN疗效显著，通过降低血清TGF-β1、CTGF水平可能是其肾脏保护作用的机制之一。
[목적]탐토아탁벌타정연합체미사탄대2형당뇨병신병（DN）환자혈청전화생장인자-β1（TGF-β1）화결체조직생장인자（CTGF）적영향。[방법]장80례DN환자수궤분위관찰조화대조조각40례，대조조급여체미사탄치료，관찰조급여아탁벌타정연합체미사탄치료，12주후분석비교량조환자적평균동맥혈압（MAP）、혈총담고순（TC）、혈감유삼지（TG）、혈기항（SCr）、혈뇨소담（BUN）、뇨백단백배설솔（UAER）급혈청TGF-β1、CTGF수평。[결과]량조환자적MAP、SCr、BUN、UAER、TGF-β1급CTGF수평균교치료전강저，차이유통계학의의（ P＜0．05）；관찰조TC、TG수평야교치료전명현하강（ P＜0．05），차기TC、TG、SCr、BUN、UAER급TGF-β1수평개선우우대조조（ P＜0．05）。[결론]아탁벌타정연합체미사탄치료DN료효현저，통과강저혈청TGF-β1、CTGF수평가능시기신장보호작용적궤제지일。
[Objective]To explore the effect of atorvastatin combined with telmisartan on serum transfer growth factor beta 1(TGF-β1 ) and connective tissue growth factor (CTGF) of type 2 diabetic nephropathy (DN) patients .[Methods]Totally 80 DN patients were randomly divided into observation group and control group with 40 cases in each .The control group was given telmisartan treatment ,while the observation group was given atorvastatin combined with telmisartan treatment .After 12 weeks ,the mean arterial blood pressure (MAP) ,serum total cholesterol(TC) ,blood triglyceride(TG) ,serum creatinine(Scr) ,blood urea nitrogen (BUN) ,urinary albumin excretion rate(UAER) and serum levels of TGF-β1 and CTGF of two groups were analyzed and compared .[Results]Compared with before treatment ,the levels of MAP ,Scr ,BUN ,UAER , TGF-β1 and CTGF in patients of two groups decreased ,and there were significant differences ( P < 0 .05) . Compared with before treatment ,the levels of TC and TG in observation group obviously decreased ( P <0 .05) ,and the improvement of levels of TC ,TG ,Scr ,BUN ,UAER and TGF-β1 in observation group was better than that in control group( P <0 .05) .[Conclusion]The curative effect of atorvastatin combined with telmisartan for the treatment of DN is significant .One of the mechanisms of renal protective effect is through lowering the serum levels of TGF-β1 and CTGF .