CAJ | 학술논문

[目的]探讨人Ⅱ型肺泡细胞表面抗原（KL-6）、ET-1在阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血清中的水平及意义。[方法]根据嗜睡量表、睡眠呼吸监测（PSG）选取75例鼾症患者，将其分为非OSAHS组、轻中度OSAHS组、重度OSAHS组三组，每组各25例，采用酶联免疫分析技术（ELISA）测定各组患者治疗干预前外周血清KL-6与ET-1水平。[结果]①血清KL-6、ET-1在非OSAHS组对象和轻中度OSAHS组血清水平差异均无统计学意义（ P ＞0．05）；重度OSAHS组患者中的水平明显高于轻中度OSAHS组和非OSAHS组（ P ＜0．05）。②血清KL-6、ET-1水平与OSAHS病情严重程度有关（ P ＜0．05），与患者性别、年龄无关（ P ＞0．05）。③OSAHS患者血清中KL-6、ET-1水平呈正相关（r＝0．942，P ＜0．05）。[结论]重度OSAHS患者出现亚临床血管内皮细胞损伤，与疾病严重程度相关，与患者性别、年龄无关；重度OSAHS患者并发心血管并发症的风险性明显高于轻中度OSA HS患者及非OSA HS患者。
[목적]탐토인Ⅱ형폐포세포표면항원（KL-6）、ET-1재조새성수면호흡잠정저통기종합정（OSAHS）환자혈청중적수평급의의。[방법]근거기수량표、수면호흡감측（PSG）선취75례한증환자，장기분위비OSAHS조、경중도OSAHS조、중도OSAHS조삼조，매조각25례，채용매련면역분석기술（ELISA）측정각조환자치료간예전외주혈청KL-6여ET-1수평。[결과]①혈청KL-6、ET-1재비OSAHS조대상화경중도OSAHS조혈청수평차이균무통계학의의（ P ＞0．05）；중도OSAHS조환자중적수평명현고우경중도OSAHS조화비OSAHS조（ P ＜0．05）。②혈청KL-6、ET-1수평여OSAHS병정엄중정도유관（ P ＜0．05），여환자성별、년령무관（ P ＞0．05）。③OSAHS환자혈청중KL-6、ET-1수평정정상관（r＝0．942，P ＜0．05）。[결론]중도OSAHS환자출현아림상혈관내피세포손상，여질병엄중정도상관，여환자성별、년령무관；중도OSAHS환자병발심혈관병발증적풍험성명현고우경중도OSA HS환자급비OSA HS환자。
[Objective]To explore the serum KL-6 and ET-1 levels in patients with obstructive sleep apnea hypopnea syndrome(OSAHS ) and the significance .[Methods]According to drowsiness scale and sleep respiratory monitoring (PSG) ,75 adult patients were chosen and divided into non-OSAHS group ,mild to moderate OSAHS group and severe OSAHS group with 25 cases in each group .ELISA was used to examine serum levels of KL-6 and ET-1 in each group be-fore intervention therapy .[Results] There was no significant difference in serum levels of KL-6 and ET-1 between non-OSAHS group and mild to moderate OSAHS group ( P>0 .05) ,but those in severe OSAHS group were obviously higher than those in mild to moderate OSAHS group and non-OSAHS group( P<0 .05) .Serum levels of KL-6 and ET-1 were related to the severity of OSAHS( P<0 .05) ,but not related to the gender and age of patients( P>0 .05) .There was positive linear correlation between serum KL-6 and ET-1(r=0 .942 ,P <0 .05) .[Conclusion]Severe OSAHS patients have sub-clinical vascular endothelial cell(VEC) injury ,which is related to the severity of OSAHS ,but not related to the gender and age of patients .The risk of cardiovascular complications in severe OSAHS patients is obviously higher than that in mild to moderate OSA HS patients and non-OSA HS patients .