CAJ | 학술논문

[目的]观察支气管肺泡灌洗（BAL ）联合胸腺肽α1在治疗老年医院获得性吸入性肺炎中的应用价值。[方法]对82例确诊为医院获得性吸入性肺炎的老年患者，均在全身应用抗菌药物、祛痰、营养支持等治疗的基础上，随机分为两组，治疗组42例，采用BAL 联合胸腺肽α1治疗，40例单纯行基础治疗而未予BAL和胸腺肽α1治疗者为对照组。比较两组临床疗效。[结果]治疗组与对照组在治疗前与治疗3d后临床肺部感染评分（CPIS）相比较差异无显著性（ P ＞0．05），治疗组治疗7 d、10 d、14 d后CPIS改善优于对照组，且两组相比较差异有显著性（ P ＜0．05）；治疗组有效率85．7％，明显高于对照组62．5％，且两组相比较差异有显著性（ P ＜0．05）。[结论]BAL联合胸腺肽α1治疗老年医院获得性吸入性肺炎能达到良好的疗效，是一种安全、实用、有效的治疗方法。
[목적]관찰지기관폐포관세（BAL ）연합흉선태α1재치료노년의원획득성흡입성폐염중적응용개치。[방법]대82례학진위의원획득성흡입성폐염적노년환자，균재전신응용항균약물、거담、영양지지등치료적기출상，수궤분위량조，치료조42례，채용BAL 연합흉선태α1치료，40례단순행기출치료이미여BAL화흉선태α1치료자위대조조。비교량조림상료효。[결과]치료조여대조조재치료전여치료3d후림상폐부감염평분（CPIS）상비교차이무현저성（ P ＞0．05），치료조치료7 d、10 d、14 d후CPIS개선우우대조조，차량조상비교차이유현저성（ P ＜0．05）；치료조유효솔85．7％，명현고우대조조62．5％，차량조상비교차이유현저성（ P ＜0．05）。[결론]BAL연합흉선태α1치료노년의원획득성흡입성폐염능체도량호적료효，시일충안전、실용、유효적치료방법。
[Objective] To observe the value of bronchoalveolar lavage(BAL) combined with thymosin α1 for the treatment of elderly patients with hospital-acquired aspiration pneumonia .[Methods]A total of 82 eld-erly patients diagnosed as hospital-acquired aspiration pneumonia were treated with systemic use of antibiotics , expectorant and nutritional support therapy .All patients were randomly divided into 2 groups .The treatment group( n=42) received BAL combined with thymosin α1 .The control group( n =40) only received the basic treatment without BAL and thymosin α1 .Clinical efficacy was compared between two groups .[Results]There was no significant difference in scores of CPIS (clinical pulmonary infection score) before treatment and 3 days after treatment between treatment group and control group ( P > 0 .05) .The improvement of CPIS in treatment group at 7d ,10d and 14d after treatment was obviously better than control group ,and there was significant difference( P<0 .05) .The effective rate of treatment group was obviously higher than that of con-trol group(85 .7% vs 62 .5% ) ,and there was significant difference( P <0 .05) .[Conclusion]BAL combined with thymosin α1 for the treatment of elderly patients with hospital-acquired aspiration pneumonia can achieve a good effect ,and is a safe ,practical and effective treatment method .