CAJ | 학술논문

[目的]研究不同剂量喘可治口服液对大鼠足趾的抗炎和豚鼠的平喘作用。[方法]采用角叉菜胶致大鼠足趾肿胀的炎症模型，观察不同剂量喘可治口服液对大鼠足趾肿胀的影响，计算肿胀度、肿胀率、抑制率。利用磷酸组胺溶液喷雾制备豚鼠哮喘模型，记录不同剂量喘可治口服液给药前后豚鼠引喘潜伏期，计算并统计引喘潜伏期延长时间。[结果]喘可治口服液高、中剂量能明显降低大鼠足趾炎症模型肿胀度和肿胀率，抑制率分别为35．71％，23．81％。与模型对照组相比，高剂量组和中剂量组均具有平喘作用，在延长引喘潜伏期方面（按时间算），中剂量组具有显著的平喘作用[给药前后豚鼠引喘潜伏期分别为（56．50±15．59） s及（105．50±17．06） s ]。高剂量组也有一定的平喘作用[给药前后豚鼠引喘潜伏期分别为（78．83±7．03）s及（92．67±15．06）s ]，但是与模型对照组比较（ P ＞0．05），并无显著性差异。[结论]喘可治口服液具有一定的抗炎、平喘作用。
[목적]연구불동제량천가치구복액대대서족지적항염화돈서적평천작용。[방법]채용각차채효치대서족지종창적염증모형，관찰불동제량천가치구복액대대서족지종창적영향，계산종창도、종창솔、억제솔。이용린산조알용액분무제비돈서효천모형，기록불동제량천가치구복액급약전후돈서인천잠복기，계산병통계인천잠복기연장시간。[결과]천가치구복액고、중제량능명현강저대서족지염증모형종창도화종창솔，억제솔분별위35．71％，23．81％。여모형대조조상비，고제량조화중제량조균구유평천작용，재연장인천잠복기방면（안시간산），중제량조구유현저적평천작용[급약전후돈서인천잠복기분별위（56．50±15．59） s급（105．50±17．06） s ]。고제량조야유일정적평천작용[급약전후돈서인천잠복기분별위（78．83±7．03）s급（92．67±15．06）s ]，단시여모형대조조비교（ P ＞0．05），병무현저성차이。[결론]천가치구복액구유일정적항염、평천작용。
[Objective]To explore the effect of different dose of Chuankezhi oral solution against inflamma-tion in toes of rats and against asthma in Guinea pigs .[Methods]Carrageenan was used to establish rat models with toe swelling .The effect of different dose of Chuankezhi oral solution on toe swelling in rats was ob-served .The swelling degree ,swelling ratio and inhibition ratio were calculated .Asthmatic guinea pig models were generated by using phosphate histamine solution spraying .Latent period of inducing asthma before and after Chuankezhi oral solution administration was recorded .The prolonged latent period of inducing asthma was calculated and counted .[Results] High and medium dosages of Chuankezhi oral solution significantly re-duced the swelling degree and ratio of rat models with toe inflammation ,and the inhibition rate was 35 .71%and 23 .81% ,respectively .Compares with model control group ,both high and medium dosage group compro-mised asthma .In terms of prolonging latent period of inducing asthma(according to the time) ,medium dosage group significantly compromised asthma(latent period of inducing asthma before and after Chuankezhi oral so-lution administration were (56 .50 ± 15 .59)s and (105 .50 ± 17 .06)s ,respectively) .High dosage group also compromised asthma to some extent(latent periods of inducing asthma before and after Chuankezhi oral solu-tion administration were (78 .83 ± 7 .03)s and (92 .67 ± 15 .06)s ,respectively ) ,but there was no significant difference between high dosage group and model control group( P>0 .05) .[Conclusion]Chuankezhi oral solu-tion has anti-inflammation and anti-asthma effect to some degree .