CAJ | 학술논문

[目的]探讨先天性肾积水患儿血清中胱抑素 C（CysC）、β2微球蛋白（β2-MG）、α1-MG表达及临床意义。[方法]采用酶联免疫吸附法（ELSIA）检测先天性肾积水患儿术前及术后血清 CysC、β2-MG、α1-MG水平，并与同期128例体检正常小儿对照组比较。[结果]先天性肾积水患儿血清中CysC、β2-MG、α1-MG水平随着积水程度的加重而增高，轻、中、重度肾积水患儿与对照组比较，血清中CysC、β2-MG、α1-MG水平均有显著性差异，病情越重差异越大（ P＜0．05，P＜0．01）；肾积水经肾盂成形术治疗后，血清中Cys C、β2-MG、α1-MG水平逐渐下降，与术前比较，差异均有统计学意义（P＜0．05），与对照组比较，差异无统计学意义（P ＞0．05）。[结论]血清CysC、β2-MG、α1-MG联合检测可作为小儿先天性肾积水术前及术后肾功能评价的常规指标。
[목적]탐토선천성신적수환인혈청중광억소 C（CysC）、β2미구단백（β2-MG）、α1-MG표체급림상의의。[방법]채용매련면역흡부법（ELSIA）검측선천성신적수환인술전급술후혈청 CysC、β2-MG、α1-MG수평，병여동기128례체검정상소인대조조비교。[결과]선천성신적수환인혈청중CysC、β2-MG、α1-MG수평수착적수정도적가중이증고，경、중、중도신적수환인여대조조비교，혈청중CysC、β2-MG、α1-MG수평균유현저성차이，병정월중차이월대（ P＜0．05，P＜0．01）；신적수경신우성형술치료후，혈청중Cys C、β2-MG、α1-MG수평축점하강，여술전비교，차이균유통계학의의（P＜0．05），여대조조비교，차이무통계학의의（P ＞0．05）。[결론]혈청CysC、β2-MG、α1-MG연합검측가작위소인선천성신적수술전급술후신공능평개적상규지표。
[Objective] To explore the value of serum CysC ,β2-MG and α1-MG in pediatric patients with con-genital hydronephrosis and its significance .[Methods]Serum levels of CysC ,β2-MG andα1-MG in pediatric patients with congenital hydronephrosis before and after operation were determined and compared with control group .[Re-sults]Serum levels of Cys C ,β2-MG andα1-MG in pediatric patients with congenital hydronephrosis increased with the aggravation of hydronephrosis .There were significant differences in serum levels of Cys C ,β2-MG andα1-MG be-tween patients with mild and moderate hydronephrosis and control group ( P<0 .05) .There were significant differ-ences in serum levels of Cys C ,β2-MG andα1-MG between patients with severe hydronephrosis and control group ( P<0 .01) .Compared with before operation ,serum levels of Cys C ,β2-MG and α1-MG after nephropyelopolasty de-creased gradually ,and there was significant difference ( P<0 .05) .Compared with the control group ,the difference was not statistically significant ( P>0 .05) .[Conclusion]Combination detection of serum CysC ,β2-MG andα1-MG can be used as a routine index for the evaluation of renal function in pediatric patient congenital hydronephrosis before and after operation .