CAJ | 학술논문

[目的]探讨瑞舒伐他汀治疗早期糖尿病肾病（ DN ）患者的临床疗效。[方法]将62例早期DN患者随机分为两组，对照组患者给予糖尿病饮食、控制血糖和降血压等常规治疗。观察组在常规治疗的基础上每晚给予瑞舒伐他汀10 mg ，两组疗程均为4周。于治疗前和治疗4周末，检测两组尿微量白蛋白排泄率（UAER）、血肌酐（SCr）、C反应蛋白（CRP）、空腹血糖（FPG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）、甘油三酯（TG）。[结果]治疗4周后，观察组UAER ，SCr ，CRP ，LDL-C ，TC ，TG 显著低于对照组（ P＜0．05）。[结论]瑞舒伐他汀在发挥调脂作用的同时，能降低CRP及UAER ，延缓早期DN 患者肾功能的恶化。
[목적]탐토서서벌타정치료조기당뇨병신병（ DN ）환자적림상료효。[방법]장62례조기DN환자수궤분위량조，대조조환자급여당뇨병음식、공제혈당화강혈압등상규치료。관찰조재상규치료적기출상매만급여서서벌타정10 mg ，량조료정균위4주。우치료전화치료4주말，검측량조뇨미량백단백배설솔（UAER）、혈기항（SCr）、C반응단백（CRP）、공복혈당（FPG）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）、총담고순（TC）、감유삼지（TG）。[결과]치료4주후，관찰조UAER ，SCr ，CRP ，LDL-C ，TC ，TG 현저저우대조조（ P＜0．05）。[결론]서서벌타정재발휘조지작용적동시，능강저CRP급UAER ，연완조기DN 환자신공능적악화。
[Objective] To explore the clinical efficacy of rosuvastatin for the treatment of patients with early diabetic nephropathy(DN) .[Methods]Totally 62 patients with early DN were randomly divided into two groups . The control group received routine therapy including diabetic diet ,blood glucose control and anti-hypertensive drugs .Based on the routine therapy ,the observation group was treated with rosuvastatin 10mg at every evening . The treatment course of two groups was 4 weeks .Urinary albumin excretion rate (UAER) ,serum creatinine (Scr) ,C-reactive protein(CRP) ,fasting plasma glucose(FPG) ,low density lipoprotein cholesterol(LDL-C) ,high density lipoprotein cholesterol(HDL-C) ,total cholesterol(TC) and triglyceride(TG) of two groups before treat-ment and at the end of treatment for 4 weeks were determined .[Results] After 4 weeks of treatment ,UAER , Scr ,CRP ,LDLC ,TC and TG in observation group were significantly lower than those in control group ( P <0 .05) .[Conclusion]Rosuvastatin can regulate blood lipids ,decrease CRP and UAER and delay the aggravation of renal function of early DN .