国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
6期
412-414,418
,共4页
]糖尿病%维生素D%糖尿病周围神经病变
]糖尿病%維生素D%糖尿病週圍神經病變
]당뇨병%유생소D%당뇨병주위신경병변
Diabetes mellitus%Vitamin D%Diabetic peripheral neuropathy
糖尿病周围神经病变(DPN)患者中普遍存在维生素D缺乏的现象.1,25(OH)2D3作为维生素D的活性形式,通过与细胞内的维生素D受体(VDR)结合发挥生物学作用.已有研究证明DPN与维生素D缺乏之间具有相关性.维生素D缺乏导致DPN的机制尚不完全清楚,但有资料证实维生素D缺乏可导致神经系统发育障碍、神经损伤及神经变性性疾病,减弱抗炎作用,促进动脉粥样硬化发展,损害胰岛β细胞功能及上调基质金属蛋白酶水平,进一步导致DPN的发生和发展.
糖尿病週圍神經病變(DPN)患者中普遍存在維生素D缺乏的現象.1,25(OH)2D3作為維生素D的活性形式,通過與細胞內的維生素D受體(VDR)結閤髮揮生物學作用.已有研究證明DPN與維生素D缺乏之間具有相關性.維生素D缺乏導緻DPN的機製尚不完全清楚,但有資料證實維生素D缺乏可導緻神經繫統髮育障礙、神經損傷及神經變性性疾病,減弱抗炎作用,促進動脈粥樣硬化髮展,損害胰島β細胞功能及上調基質金屬蛋白酶水平,進一步導緻DPN的髮生和髮展.
당뇨병주위신경병변(DPN)환자중보편존재유생소D결핍적현상.1,25(OH)2D3작위유생소D적활성형식,통과여세포내적유생소D수체(VDR)결합발휘생물학작용.이유연구증명DPN여유생소D결핍지간구유상관성.유생소D결핍도치DPN적궤제상불완전청초,단유자료증실유생소D결핍가도치신경계통발육장애、신경손상급신경변성성질병,감약항염작용,촉진동맥죽양경화발전,손해이도β세포공능급상조기질금속단백매수평,진일보도치DPN적발생화발전.
Vitamin D deficiency is commonly seen in patients with diabetic peripheral neuropathy (DPN).Vitamin D,with 1,25 (OH) 2 D3 as its active form,takes effect by combination with vitamin D receptor (VDR).It has been documented that DPN is relative with vitamin D deficiency.No specific studies were performed for the mechanism which vitamin D deficiency leads to DPN.While it has been proved that vitamin D deficiency plays a role in developmental disorder of nervous system,nerve injury,neurodegenerative diseases,attenuating anti-inflammatory effects,promoting atherosclerosis,damaging islet β cell function and upgrading matrix netalloproteinases,thereby leading to occurrence and development of DPN.
