CAJ | 학술논문

P53作为转录因子，其转录激活功能维持了基因组的稳定性，对防止肿瘤的形成起着重要作用，是目前研究得最为广泛、深入的抑癌基因，被称为“基因卫士”。P53家族的成员p63、p73与p53在DNA结合结构域上有高度的同源性，某些p53家族亚型可以与p53-反应基因相结合起着转录激活的作用，另外一些则起着负性调节作用。肺癌是世界上患病率最高的恶性肿瘤之一，p53家族成员在肺癌中的异常表达与肺癌的发生有密切联系，并导致不良的预后及对放疗、化疗的抵抗。对p53家族成员在肺癌致病机制的深入研究可有助于为临床提供合理的化疗方案及靶向治疗策略。本文着重回顾总结p53家族成员在肺癌发生、化疗敏感性以及肺癌靶向治疗中的独特的作用。
P53작위전록인자，기전록격활공능유지료기인조적은정성，대방지종류적형성기착중요작용，시목전연구득최위엄범、심입적억암기인，피칭위“기인위사”。P53가족적성원p63、p73여p53재DNA결합결구역상유고도적동원성，모사p53가족아형가이여p53-반응기인상결합기착전록격활적작용，령외일사칙기착부성조절작용。폐암시세계상환병솔최고적악성종류지일，p53가족성원재폐암중적이상표체여폐암적발생유밀절련계，병도치불량적예후급대방료、화료적저항。대p53가족성원재폐암치병궤제적심입연구가유조우위림상제공합리적화료방안급파향치료책략。본문착중회고총결p53가족성원재폐암발생、화료민감성이급폐암파향치료중적독특적작용。
hTe transcription activation of p53 plays an important role in the maintenance of genetic stability. P53 is an intensive study tumor suppressor, which has been called the”gene guider”. hTe p53 family members p63, p73 have high homologous sequence with p53. Some of them can bind to the p53-responsive genes and transcript the downstream genes. Human lung cancer is one of the most common malignant tumors in the world. Abnormality of the p53 gene is the signiifcant event in lung cancers, which leads to the poor prognosis and the resistance of chemotherapy. A deep understanding of the rela-tionship between p53 family members and lung cancers can provide a more reasonably targeted clinical approach. hTis paper will focus on the special function of p53 family members in the development, chemosensitivity and target treatment of lung cancer.