现代诊断与治疗
現代診斷與治療
현대진단여치료
MODERN DIAGNOSIS AND TREATMENT
2013年
8期
1694-1695
,共2页
复发鼻咽癌%I区淋巴结转移%VEGF
複髮鼻嚥癌%I區淋巴結轉移%VEGF
복발비인암%I구림파결전이%VEGF
Recurrent nasopharyngeal carcinoma%Level I metastasis%VEGF
目的探讨复发鼻咽癌发生I区淋巴结转移的危险因素。方法对51例复发鼻咽癌患者，应用免疫组化法检测原发及复发鼻咽活检组织VEGF及P53、MDM2、P21 WAF1、P21 ras蛋白的表达，采用卡方分析法检验I区转移的危险因素。结果在51例中发生I区转移9例；当鼻咽癌侵及鼻腔同时伴有VEGF高表达时， I区转移率（37．5％）明显高于其它患者（8．6％），P＝0．020。结论鼻咽癌侵及鼻腔与VEGF表达能在一定程度上反映复发患者I区转移的风险。
目的探討複髮鼻嚥癌髮生I區淋巴結轉移的危險因素。方法對51例複髮鼻嚥癌患者，應用免疫組化法檢測原髮及複髮鼻嚥活檢組織VEGF及P53、MDM2、P21 WAF1、P21 ras蛋白的錶達，採用卡方分析法檢驗I區轉移的危險因素。結果在51例中髮生I區轉移9例；噹鼻嚥癌侵及鼻腔同時伴有VEGF高錶達時， I區轉移率（37．5％）明顯高于其它患者（8．6％），P＝0．020。結論鼻嚥癌侵及鼻腔與VEGF錶達能在一定程度上反映複髮患者I區轉移的風險。
목적탐토복발비인암발생I구림파결전이적위험인소。방법대51례복발비인암환자，응용면역조화법검측원발급복발비인활검조직VEGF급P53、MDM2、P21 WAF1、P21 ras단백적표체，채용잡방분석법검험I구전이적위험인소。결과재51례중발생I구전이9례；당비인암침급비강동시반유VEGF고표체시， I구전이솔（37．5％）명현고우기타환자（8．6％），P＝0．020。결론비인암침급비강여VEGF표체능재일정정도상반영복발환자I구전이적풍험。
Object: The objective of this study was to find the risk factors for level I metastasis in recurrent nasopharyngeal carcinoma ( NPC) .Methods fifty one recurrent NPC were selected for the research .The expression level of VEGF, P53, MDM2, P21WAF1, P21ras protein were examined in IHC method.Theχ2 test was used to verify the risk factors .Result There are 9 cases of level I metastasis in all 51 cases. When the nasal cavity involvement accompanied with high expression of VEGF , the level I metastasis rate (37.5%) was significant higher others (8.6%),P=0.020.Conclusion The nasal cavity involvement and expression level of VEGF maybe a valuable index reflex the risk of level I metastasis .
