CAJ | 학술논문

目的：探讨滋肾活血汤对糖尿病（DM）大鼠血糖，空腹胰岛素，血脂，肾功能及血管炎性指标ET、NO、INS、TNF-α的影响。方法：选取健康雌性Wister大鼠42只分为模型对照组、中药组、二甲双胍组、中药+二甲双胍组、空白对照组进行灌胃，给药8周后进行生化、血管炎性指标、肾功能检测。结果：滋肾活血汤能显著降低糖尿病大鼠血清NO、INS、TNF-α、TG、BUN、CREA、UA水平。结论：滋肾活血汤能明显改善糖尿病大鼠血管炎症，并有明显的肾脏保护作用，早期联用小剂量二甲双胍时其优势更加显著。
목적：탐토자신활혈탕대당뇨병（DM）대서혈당，공복이도소，혈지，신공능급혈관염성지표ET、NO、INS、TNF-α적영향。방법：선취건강자성Wister대서42지분위모형대조조、중약조、이갑쌍고조、중약+이갑쌍고조、공백대조조진행관위，급약8주후진행생화、혈관염성지표、신공능검측。결과：자신활혈탕능현저강저당뇨병대서혈청NO、INS、TNF-α、TG、BUN、CREA、UA수평。결론：자신활혈탕능명현개선당뇨병대서혈관염증，병유명현적신장보호작용，조기련용소제량이갑쌍고시기우세경가현저。
Objective: To explore the effect of Kidney-Enrichment And Blood-Quickening Decoction on blood sugar, fast-ing insulin, blood fat, renal function, and the vasculitis index of ET, NO, INS and TNF-α. Methods: 42 female Wister rats were divided into model control group, Chinese medicine group, melbine group, Chinese medicine-melbine group and blank control group. After intragastric administration of 8 weeks, the biochemical indicator, vasculitis index and renal function were tested. Results: Kidney-Enrichment And Blood-Quickening Decoction can reduce the serum NO, INS, TNF-α, TG, BUN, CREA and UA in Type 2 diabetic rats. Conclusion: Kidney-Enrichment And Blood-Quickening Decoction can relieve the vas-cular inflammation, with protective function on kidney. And the function was more obvious with low dosage of melbine in ear-ly stage.