CAJ | 학술논문

目的：探讨紫杉醇联合替吉奥治疗老年晚期胃癌的近期疗效、不良反应及生存期。方法：2010年1月至2012年12月共28例老年（年龄≥65岁）晚期胃癌患者，采用紫杉醇静脉化疗联合替吉奥胶囊口服化疗，具体治疗方案：紫杉醇135 mg/m2静脉滴注，d1；替吉奥胶囊60 mg（体表面积≥1.5 m2）口服，每天2次，d1～14；28天为一周期，2个周期评价疗效。结果：28例患者均可评价疗效，CR 0例，PR 5例，SD 21例，PD 2例，有效率为17.8%，疾病控制率为95.4%，中位总生存时间为9.5个月。主要不良反应为骨髓抑制及手足综合征，以1～2级为主，无治疗相关并发症及死亡。结论：紫杉醇联合替吉奥治疗老年晚期胃癌疗效肯定，且不良反应较轻，老年患者可耐受，值得临床进一步观察研究。
목적：탐토자삼순연합체길오치료노년만기위암적근기료효、불량반응급생존기。방법：2010년1월지2012년12월공28례노년（년령≥65세）만기위암환자，채용자삼순정맥화료연합체길오효낭구복화료，구체치료방안：자삼순135 mg/m2정맥적주，d1；체길오효낭60 mg（체표면적≥1.5 m2）구복，매천2차，d1～14；28천위일주기，2개주기평개료효。결과：28례환자균가평개료효，CR 0례，PR 5례，SD 21례，PD 2례，유효솔위17.8%，질병공제솔위95.4%，중위총생존시간위9.5개월。주요불량반응위골수억제급수족종합정，이1～2급위주，무치료상관병발증급사망。결론：자삼순연합체길오치료노년만기위암료효긍정，차불량반응교경，노년환자가내수，치득림상진일보관찰연구。
Objective:To explore the recent results of taxol combined with tegafur gimeracil and oteracil potassium capsules (TGO) in the treatment of the elderly with advanced gastric cancer, their adverse reactions and survival period. Methods:Twenty-eight elderly cases over 65 years old with advanced gastric cancer were treated with taxol combined with TGO from Jan. 2010 to Dec. 2012. Taxol was administrated by intravenous infusion at 135 mg/m2, d1 and TGO was orally taken twice daily at 60 mg (body surface area≥1.5 m2), d1~14 for 28-days as a cycle. The efifcacy was evaluated after two cycles. Results:All of 28 cases were able to be evaluated, in which there were 0 case of CR, 5 cases of PR, 21 cases of SD and 2 cases of PD. Their effective rate was 17.8%, and control rate 95.4%. The median overall survival time was 9.5 months. The main adverse reactions were myelosuppression and hand-foot syndrome in 1~2 grades, but there was neither complication nor death related to the treatment. Conclusion:The efifcacy of taxol combined with TGO in the treatment of the elderly with advanced gastric cancer has been conifrmed and their adverse reactions are slight. This therapy can be tolerated by the elderly and is worthy of further observation and study.