CAJ | 학술논문

目的：经外周静脉（手背静脉）泵入腺苷三磷酸（ATP）的方法测定血流储备分数（FFR），并通过与标准的测量方法[深静脉（股静脉）泵入ATP]测量FFR的对比研究，评价经外周静脉泵入不同剂量ATP测定FFR的可行性。探讨经手背静脉泵入ATP测定是否能够准确测量FFR。方法针对航天中心医院27例患者冠状动脉造影术中的31条冠状动脉病变血管，进行外周静脉和股静脉冠状动脉造影术及两种途径测定的FFR数值测量与数据分析。结果经手背静脉泵入ATP[≥140μg/（kg · min）]测量的4组FFR值与标准方法测量FFR值的一致性、相关性。两种途径注射ATP后心率、PR间期、不良反应发生率比较，差异无统计学意义。但手背静脉ATP注射剂量为160μg/（kg·min）时，FFR测量结果与股静脉组FFR结果一致性与相关性最好（R2=0.904， P=0.001）。经手背静脉泵入ATP达FFR值时间[从（53.7±15.8）s到（58.2±11.6）s]较标准方法[（48.7±17.9）s]延长（P=0.015）。结论经手背静脉泵入ATP测量FFR值可与标准方法取得相似的结果，使用手背静脉注射ATP[剂量160μg/（kg·min）]测量冠状动脉FFR具有临床实用价值。
목적：경외주정맥（수배정맥）빙입선감삼린산（ATP）적방법측정혈류저비분수（FFR），병통과여표준적측량방법[심정맥（고정맥）빙입ATP]측량FFR적대비연구，평개경외주정맥빙입불동제량ATP측정FFR적가행성。탐토경수배정맥빙입ATP측정시부능구준학측량FFR。방법침대항천중심의원27례환자관상동맥조영술중적31조관상동맥병변혈관，진행외주정맥화고정맥관상동맥조영술급량충도경측정적FFR수치측량여수거분석。결과경수배정맥빙입ATP[≥140μg/（kg · min）]측량적4조FFR치여표준방법측량FFR치적일치성、상관성。량충도경주사ATP후심솔、PR간기、불량반응발생솔비교，차이무통계학의의。단수배정맥ATP주사제량위160μg/（kg·min）시，FFR측량결과여고정맥조FFR결과일치성여상관성최호（R2=0.904， P=0.001）。경수배정맥빙입ATP체FFR치시간[종（53.7±15.8）s도（58.2±11.6）s]교표준방법[（48.7±17.9）s]연장（P=0.015）。결론경수배정맥빙입ATP측량FFR치가여표준방법취득상사적결과，사용수배정맥주사ATP[제량160μg/（kg·min）]측량관상동맥FFR구유림상실용개치。
Objective To compare and evaluate fractional flow reserve (FFR) by intravenous infusion of adenosine 5’-triphosphate (ATP) through femoral veins and hand dosal veins. To find the feasibility of measuring FFR through ATP infusion at hand dosal veins. Methods A total of 27 patients receiving coronary angiography (CAG) were enrolled. FFR was measured by intravenous injection of ATP through femoral veins and hand dosal veins separately in 31 stenosed coronary arteries. Results A linear correlation between ATP infusion measuring FFR through femoral and hand dosal veins was observed. Heart rates, PR intervals and side effects were of no difference between the 2 routes of ATP infusion (P=0.79, P=0.56, P=0.85). It indicated that ATP infusion[160μg/(kg·min)]measuring FFR through hand dosal veins was compatable to which measuring FFR though femoral veins (y=0.945x+0.0043, R2=0.904, P=0.001). Compared with ATP infusion by femoral vein[from (53.7±15.8) s to (58.2±11.6) s], the time to FFR by infusion ATP measurement by hand dosal veins was longer[(48.7±17.9) s, P=0.015]. Conclusions The FFR measurement through ATP infusion at hand dosal veins has similar results with the FFR measured by femoral veins ATP infusion.