中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
9期
1343-1344
,共2页
心排出量,低%肽素激素
心排齣量,低%肽素激素
심배출량,저%태소격소
Cardiac Oulput,low%Peptide Hormones
目的 探讨血浆B型脑钠肽前体N端片段(NT-pro-BNP)水平用于心功能不全疾病中的诊断和预后评估的价值.方法 对48例心功能不全患者按原发性疾病不同分为高血压心脏病组15例,冠心病组16例,慢性肺心病组17例；同时选择40例作为健康对照组,在入院第一天和治疗后病情好转稳定1周测定血浆pro-BNP水平.结果 高血压心脏病组、冠心病组、慢性肺心病组治疗前血浆pro-BNP水平均明显高于健康对照组(t=2.98、2.98、2.98,P＜0.01)；治疗后NT-pro-BNP水平均明显低于治疗前(t=2.56、2.75、2.88,P＜0.05,P＜0.01,P＜0.01)；随着心力衰竭程度的加重,NT-pro-BNP水平逐渐升高(t=2.78,P＜0.05).结论 高血压心脏病急性心衰、冠心病慢性心衰和慢性肺心病急性加重期合并右心衰竭的患者血浆NT-pro-BNP水平明显增高,病情好转而下降,血浆NT-pro-BNP水平可用于心功能不全患者的病情监测及预后评估.
目的 探討血漿B型腦鈉肽前體N耑片段(NT-pro-BNP)水平用于心功能不全疾病中的診斷和預後評估的價值.方法 對48例心功能不全患者按原髮性疾病不同分為高血壓心髒病組15例,冠心病組16例,慢性肺心病組17例；同時選擇40例作為健康對照組,在入院第一天和治療後病情好轉穩定1週測定血漿pro-BNP水平.結果 高血壓心髒病組、冠心病組、慢性肺心病組治療前血漿pro-BNP水平均明顯高于健康對照組(t=2.98、2.98、2.98,P＜0.01)；治療後NT-pro-BNP水平均明顯低于治療前(t=2.56、2.75、2.88,P＜0.05,P＜0.01,P＜0.01)；隨著心力衰竭程度的加重,NT-pro-BNP水平逐漸升高(t=2.78,P＜0.05).結論 高血壓心髒病急性心衰、冠心病慢性心衰和慢性肺心病急性加重期閤併右心衰竭的患者血漿NT-pro-BNP水平明顯增高,病情好轉而下降,血漿NT-pro-BNP水平可用于心功能不全患者的病情鑑測及預後評估.
목적 탐토혈장B형뇌납태전체N단편단(NT-pro-BNP)수평용우심공능불전질병중적진단화예후평고적개치.방법 대48례심공능불전환자안원발성질병불동분위고혈압심장병조15례,관심병조16례,만성폐심병조17례；동시선택40례작위건강대조조,재입원제일천화치료후병정호전은정1주측정혈장pro-BNP수평.결과 고혈압심장병조、관심병조、만성폐심병조치료전혈장pro-BNP수평균명현고우건강대조조(t=2.98、2.98、2.98,P＜0.01)；치료후NT-pro-BNP수평균명현저우치료전(t=2.56、2.75、2.88,P＜0.05,P＜0.01,P＜0.01)；수착심력쇠갈정도적가중,NT-pro-BNP수평축점승고(t=2.78,P＜0.05).결론 고혈압심장병급성심쇠、관심병만성심쇠화만성폐심병급성가중기합병우심쇠갈적환자혈장NT-pro-BNP수평명현증고,병정호전이하강,혈장NT-pro-BNP수평가용우심공능불전환자적병정감측급예후평고.
Objective To study the clinical significance of plasma N-teminal pro brain natriuretic peptide (NT-pro-BNP) level in diagnosis and evaluation prognosis of patients with different heart failure.Methods Plasma NT-pro-BNP level was detected and compared in all patients at the first day and a week after the patients' condition turn better.Results The level of plasma NT-pro-BNP for the high blood pressure's heart disease and the chronic heart failure of coronary heart disease and the chronic heart failure of cor pulmonale were significantly higher than normal (t =2.98,t =2.98,t =2.98,P ＜ 0.01).The level of plasma NT-pro-BNP was reduced after treatment (t =2.56,t =2.75,t =2.88,P ＜ 0.05,P ＜ 0.01,P ＜ 0.01).The level of plasma NT-pro-BNP was gradually increased by the increased degree of the heart failure(t =2.78,P ＜ 0.05).Conclusion The levels of plasma NT-pro-BNP at acute stage for the high blood pressure's heart disease and the chronic heart failure of coronary heart disease and the chronic heart failure of cor pulmonale were increased obviously and descend by the patients' condition return.The level of plasma NT-pro-BNP can monitor patients' condition and estimate the heart failure patients' prognosis.
