CAJ | 학술논문

下丘脑性肥胖是指下丘脑能量稳态调节系统结构或功能损伤引起的食欲亢进和短期内体重显著增加综合征.其临床特征还包括能量消耗下降、合并多种下丘脑-垂体功能减退以及血糖、血脂、血压等代谢改变,部分可合并昼夜节律、体温、渴感及情绪调节异常.发病机制涉及下丘脑能量调节通路受损,胰岛素、瘦素、ghrelin等体液因子在中枢作用异常,自主神经功能紊乱等方面.其治疗包括常规生活方式干预、药物治疗及减重手术等.
하구뇌성비반시지하구뇌능량은태조절계통결구혹공능손상인기적식욕항진화단기내체중현저증가종합정.기림상특정환포괄능량소모하강、합병다충하구뇌-수체공능감퇴이급혈당、혈지、혈압등대사개변,부분가합병주야절률、체온、갈감급정서조절이상.발병궤제섭급하구뇌능량조절통로수손,이도소、수소、ghrelin등체액인자재중추작용이상,자주신경공능문란등방면.기치료포괄상규생활방식간예、약물치료급감중수술등.
Hypothalamic obesity is defined as the significant polyphagia and rapid weight gain due to a variety of structural or functional damage to the hypothalamic regulatory centers of energy homeostasis.Its clinical characteristics also include reduced energy expenditure,multiple deficits of hypothalamic-pituitary function and metabolic disturbances of blood glucose,lipid profile and blood pressure.Some patients may as well develop abnormal circadian rhythms,impaired regulation of body temperature,thirst perception and mood.The pathogenetic mechanisms underlying hypothalamic obesity include defects in the hypothalamic weightregulating pathways,dysfunction of afferent peripheral humoral signals in the central nervous system,such as leptin,insulin,ghrelin,etc,and autonomic imbalance.The treatment of hypothalamic obesity includes conventional lifestyle modifications,several agents and bariatric surgery.