CAJ | 학술논문

目的：探讨国产长春西汀片治疗脑梗死恢复期患者的效果及对血液流变学指标的影响，并与进口同类药物进行对比。方法将104例患者随机分为治疗组（n=75）和对照组（n=29）。治疗组应用国产长春西汀片5 mg/次，3次/d口服。对照组应用卡兰片5 mg/次，3次/d口服。两组疗程均为4周。监测2组血液流变学指标。结果国产长春西汀片对脑梗死恢复期的总有效率为62.7%，对照组总有效率为62.1%，二者差异无统计学意义（P＞0.05）。两组对自觉症状的疗效差异亦无统计学意义（P＞0.05）。两组治疗后血液流变学各项指标较治疗前均有明显下降（P＜0.05或P＜0.01）。无明显不良反应。结论国产长春西汀片治疗脑梗死恢复期有效，可降低血液流变学各项指标，改善血液的高凝、高聚状态，且与进口同类药物相比疗效无显著差别。
목적：탐토국산장춘서정편치료뇌경사회복기환자적효과급대혈액류변학지표적영향，병여진구동류약물진행대비。방법장104례환자수궤분위치료조（n=75）화대조조（n=29）。치료조응용국산장춘서정편5 mg/차，3차/d구복。대조조응용잡란편5 mg/차，3차/d구복。량조료정균위4주。감측2조혈액류변학지표。결과국산장춘서정편대뇌경사회복기적총유효솔위62.7%，대조조총유효솔위62.1%，이자차이무통계학의의（P＞0.05）。량조대자각증상적료효차이역무통계학의의（P＞0.05）。량조치료후혈액류변학각항지표교치료전균유명현하강（P＜0.05혹P＜0.01）。무명현불량반응。결론국산장춘서정편치료뇌경사회복기유효，가강저혈액류변학각항지표，개선혈액적고응、고취상태，차여진구동류약물상비료효무현저차별。
Objective To investigate the therapeutic effect of national vinpocetine on patients with cerebral infarction at recovery stage and its effect on their hemorheological parameters. Methods 104 patients were di-vided into treatment group (n=75) and control group (n=29) randomly. The treatment group was administered with national vinpocetine 5 mg tid orally for 4 weeks, while the control group administered with imported vinpocetine. Hemorheological parameters were monitored in the two groups. Results The total effective rate of treatment group on recovery-stage cerebral infarction was 62.7%, without signiifcant difference with control group (62.1%, P>0.05). No signiifcant difference was found with the effect on the subjective symptoms between the two groups (P>0.05). Values of hemorheological indicators decreased signiifcantly after treatment in both groups (P<0.05 or P<0.01). No obvious adverse effects were observed. Conclusion National vinpocetine is effective for the treatment of recovery-stage cerebral infarction and can reduce the blood viscosity of patients.