中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
9期
960-963
,共4页
武秀玲%张磊%尹莉莉%武晶晶%夏元亮%韩忠奎
武秀玲%張磊%尹莉莉%武晶晶%夏元亮%韓忠奎
무수령%장뢰%윤리리%무정정%하원량%한충규
糖尿病,2型%胰腺肿瘤%血糖
糖尿病,2型%胰腺腫瘤%血糖
당뇨병,2형%이선종류%혈당
Diabetes mellitus,type2%Pancreatic neoplasms%Blood glucose
目的 探讨2型糖尿病(T2DM)患者糖链抗原(CA) 19-9与血糖水平的关系. 方法 选取784例T2DM患者和197例健康体检者,记录年龄、病程、体质指数(BMI)、收缩压、舒张压、空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血尿酸、C肽、CA19-9等指标.按不同HbA1c水平及CA19-9水平分组,同时分析血清CA 19-9与上述指标的相关关系. 结果 与对照组比较,T2DM患者CA19-9水平增高[(22.08±14.94) U/ml与(10.24±6.31) U/ml,t=12.10,P=0.000].不同HbA1c水平的T2DM患者收缩压、舒张压、FBG、PBG、C肽、TC、TG、LDL-C、血尿酸水平均高于对照组,HDL C水平低于对照组,差异具有统计学意义(均P＜0.05).随着HbA1c的增高,T2DM患者中的FBG、PBG及CA19-9水平增高,HbA1c≤6.5％者、6.5％＜HbA1c≤7.5％者和HbA1c＞7.5％者FBG分别为(6.36±3.70) mmol/L、(9.01±4.01) mmol/L、(11.96±4.73) mmol/L,PBG分别为(9.69±3.21) mmol/L、(12.18±5.54) mmol/L、(15.27±5.08) mmol/L,CA19-9水平分别为(14.33±11.72) U/ml、(18.76±14.39) U/ml、(25.96±17.52) U/ml(F=14.38、12.94、17.25,均P＜0.05).CA19 9增高组的FBG、HbA1c水平及胰腺癌发生率均明显高于CA19-9正常组[(11.71±5.48) mmol/L与(9.78±4.38) mmol/L,(7.49±4.12)％与(6.33±3.70)％,7.8％与0％,t=-3.51、-2.55,x2 =83.58,均P＜0.05].Pearson相关分析显示T2DM组的CA19 9水平与HbA1c(r=0.281,P=0.007)、FBG(r=0.134,P=0.040)呈正相关；多元logistic回归分析显示FBG、HbA1c与T2DM患者CA19-9升高有关(OR=1.226、1.582,P=0.019、0.026). 结论 T2DM患者血清CA19 9水平显著高于健康人群,且与血糖控制水平相关.
目的 探討2型糖尿病(T2DM)患者糖鏈抗原(CA) 19-9與血糖水平的關繫. 方法 選取784例T2DM患者和197例健康體檢者,記錄年齡、病程、體質指數(BMI)、收縮壓、舒張壓、空腹血糖(FBG)、餐後2h血糖(PBG)、糖化血紅蛋白(HbA1c)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、血尿痠、C肽、CA19-9等指標.按不同HbA1c水平及CA19-9水平分組,同時分析血清CA 19-9與上述指標的相關關繫. 結果 與對照組比較,T2DM患者CA19-9水平增高[(22.08±14.94) U/ml與(10.24±6.31) U/ml,t=12.10,P=0.000].不同HbA1c水平的T2DM患者收縮壓、舒張壓、FBG、PBG、C肽、TC、TG、LDL-C、血尿痠水平均高于對照組,HDL C水平低于對照組,差異具有統計學意義(均P＜0.05).隨著HbA1c的增高,T2DM患者中的FBG、PBG及CA19-9水平增高,HbA1c≤6.5％者、6.5％＜HbA1c≤7.5％者和HbA1c＞7.5％者FBG分彆為(6.36±3.70) mmol/L、(9.01±4.01) mmol/L、(11.96±4.73) mmol/L,PBG分彆為(9.69±3.21) mmol/L、(12.18±5.54) mmol/L、(15.27±5.08) mmol/L,CA19-9水平分彆為(14.33±11.72) U/ml、(18.76±14.39) U/ml、(25.96±17.52) U/ml(F=14.38、12.94、17.25,均P＜0.05).CA19 9增高組的FBG、HbA1c水平及胰腺癌髮生率均明顯高于CA19-9正常組[(11.71±5.48) mmol/L與(9.78±4.38) mmol/L,(7.49±4.12)％與(6.33±3.70)％,7.8％與0％,t=-3.51、-2.55,x2 =83.58,均P＜0.05].Pearson相關分析顯示T2DM組的CA19 9水平與HbA1c(r=0.281,P=0.007)、FBG(r=0.134,P=0.040)呈正相關；多元logistic迴歸分析顯示FBG、HbA1c與T2DM患者CA19-9升高有關(OR=1.226、1.582,P=0.019、0.026). 結論 T2DM患者血清CA19 9水平顯著高于健康人群,且與血糖控製水平相關.
목적 탐토2형당뇨병(T2DM)환자당련항원(CA) 19-9여혈당수평적관계. 방법 선취784례T2DM환자화197례건강체검자,기록년령、병정、체질지수(BMI)、수축압、서장압、공복혈당(FBG)、찬후2h혈당(PBG)、당화혈홍단백(HbA1c)、총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、혈뇨산、C태、CA19-9등지표.안불동HbA1c수평급CA19-9수평분조,동시분석혈청CA 19-9여상술지표적상관관계. 결과 여대조조비교,T2DM환자CA19-9수평증고[(22.08±14.94) U/ml여(10.24±6.31) U/ml,t=12.10,P=0.000].불동HbA1c수평적T2DM환자수축압、서장압、FBG、PBG、C태、TC、TG、LDL-C、혈뇨산수평균고우대조조,HDL C수평저우대조조,차이구유통계학의의(균P＜0.05).수착HbA1c적증고,T2DM환자중적FBG、PBG급CA19-9수평증고,HbA1c≤6.5％자、6.5％＜HbA1c≤7.5％자화HbA1c＞7.5％자FBG분별위(6.36±3.70) mmol/L、(9.01±4.01) mmol/L、(11.96±4.73) mmol/L,PBG분별위(9.69±3.21) mmol/L、(12.18±5.54) mmol/L、(15.27±5.08) mmol/L,CA19-9수평분별위(14.33±11.72) U/ml、(18.76±14.39) U/ml、(25.96±17.52) U/ml(F=14.38、12.94、17.25,균P＜0.05).CA19 9증고조적FBG、HbA1c수평급이선암발생솔균명현고우CA19-9정상조[(11.71±5.48) mmol/L여(9.78±4.38) mmol/L,(7.49±4.12)％여(6.33±3.70)％,7.8％여0％,t=-3.51、-2.55,x2 =83.58,균P＜0.05].Pearson상관분석현시T2DM조적CA19 9수평여HbA1c(r=0.281,P=0.007)、FBG(r=0.134,P=0.040)정정상관；다원logistic회귀분석현시FBG、HbA1c여T2DM환자CA19-9승고유관(OR=1.226、1.582,P=0.019、0.026). 결론 T2DM환자혈청CA19 9수평현저고우건강인군,차여혈당공제수평상관.
Objective To study the relationship between serum carbohydrate antigen 19-9 (CA19-9) and blood glucose level in patients with type 2 diabetes (T2DM).Methods Totally 784 T2DM patients and 197 healthy controls were enrolled in this study.Age,duration,body mass index (BMI),systolic blood pressure (SBP),diastolic blood pressure (DBP),levels of fasting blood glucose (FBG),postprandial blood glucose (PBG),hemoglobin A1c (HbA1c),total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),blood uric acid,C peptide and CA 19-9 were recorded.Patients were divided into different groups according to the levels of HbA1 c and CA 19-9.The relationship between CA19-9 and influencing factors was analyzed.Results CA19-9 level was increased in T2DM patients compared with healthy controls [(22.08±14.94) U/mlvs.(10.24±6.31) U/ml,t=12.10,P＜0.001].The levels of SBP,DBP,FBG,PBG,C peptide,TC,TG,LDL and UA were higher and HDL C level was lower in T2DM patients than in healthy controls (all P＜0.05).The levels of FBG,PBG and CA19-9 were increased along with the increase of HbA1c level in T2MD patients with HbA1c level under 6.5％,T2MD patients with HbA1c level from 6.5％ to 7.5％,T2MD patients with HbA1c level over 7.5％ [FBG:(6.36±3.70) mmol/L,(9.01±4.01) mmol/L,(11.96±4.73) mmol/L;PBG:(9.69±3.21) mmol/L,(12.18±5.54) mmol/L,(15.27±5.08) mmol/L; CA19 9 (14.33±11.72) U/ml,(18.76±14.39) U/ml,(25.96±17.52) U/ml,respectively,all P＜0.05].The levels of FBG,HbA1c and pancreatic cancer incidence were higher in patients with elevated CA19-9 than with normal CA19-9 [(11.71±5.48)mmol/L vs.(9.78±4.38)mmol/L,(7.49±4.12)％ vs.(6.33±3.70)％,0％ vs.7.8％,t=-3.51,2.55,x2=83.58,allP＜0.05].Pearson correlation analysis showed that CA19-9 level was positively correlated with the levels of HbA 1 c and FBG in T2DM patients (r=0.281,0.134,both P＜0.05).Multiple Logistic regression analysis showed that the levels of FBG and HbA1c were correlated with the increase of CA19 9 in T2DM patients(OR=0.801,0.947,P=0.019,0.026).Conclusions Serum CA19-9 level is significantly increased in T2DM patients compared with the healthy people.Serum CA19-9 level is correlated with blood glucose control.
