CAJ | 학술논문

目的：研究重型颅脑损伤患者高压氧（HBO）联合依达拉奉治疗重型脑外伤后NO、ET的变化，并观察治疗效果。方法随机选取30例符合标准的急性重度颅脑外伤患者作为治疗组，同时随机抽取符合标准的30例患者作为对照组，予常规治疗。治疗组在常规治疗的基础上，给予早期高压氧治疗，并予依达拉奉静滴，30 mg/d，共用28 d，于伤后1 d、4 d、14 d用放射免疫法检测血浆NO-1、ET结果的变化。伤后3个月行预后判断GOS评分比较。结果治疗组和对照组治疗前血浆指标差异无统计学意义（P＞0.05），治疗后4 d、14 d，两组数据差异均有统计学意义（P＜0.01），且治疗组患者GOS评分明显好于对照组。结论高压氧联合依达拉奉治疗能有效降低颅脑外伤患者血清NO、ET的数值，改善颅脑外伤的血液流变，从而改善患者预后。
목적：연구중형로뇌손상환자고압양（HBO）연합의체랍봉치료중형뇌외상후NO、ET적변화，병관찰치료효과。방법수궤선취30례부합표준적급성중도로뇌외상환자작위치료조，동시수궤추취부합표준적30례환자작위대조조，여상규치료。치료조재상규치료적기출상，급여조기고압양치료，병여의체랍봉정적，30 mg/d，공용28 d，우상후1 d、4 d、14 d용방사면역법검측혈장NO-1、ET결과적변화。상후3개월행예후판단GOS평분비교。결과치료조화대조조치료전혈장지표차이무통계학의의（P＞0.05），치료후4 d、14 d，량조수거차이균유통계학의의（P＜0.01），차치료조환자GOS평분명현호우대조조。결론고압양연합의체랍봉치료능유효강저로뇌외상환자혈청NO、ET적수치，개선로뇌외상적혈액류변，종이개선환자예후。
Objective To investigate the effects of hyperbaric oxygen treatment combined with edaravone on endothelin (ET) and NO in serum of patients with severe traumatic brain injury and its clinical signiifcance. Meth-ods To select 60 cases patients of heavy craniocerebral injury with GCS score of 3~8. 30 patients (therapy group) were treated by hyperbaric oxygen treatment and edaravone besides the conventional therapy:dewatering, hemo-stasis, advancing consciousness, pressing down the gastric acid excretion, trophicing nerve, expanding blood ves-sel and so on. And other 30 patients (control group) were treated by conventional therapy. The dynamic changes of serum ET-1 and NO at days 1, 4 and 14 respectively after trauma were monitored using ELISA. Then analyzing these data by statistical methods. Results Levels of serum ET-1 and NO increased more signiifcantly in the control group than those in the therapy group (P<0.05). The effect of hyperbaric oxygenation treatment combined with edaravone on heavy craniocerebral injury is better than the effect of conventional therapy. These methods have statistical differences. Conclusion The treatment of hyperbaric oxygen combined with edaravone can regulate se-rum cytokines levels in patients with severe brain injury, suppress the immune damage and improve the prognosis.