中国医药
中國醫藥
중국의약
CHINA MEDICINE
2013年
3期
384-386
,共3页
林庆娟%马秀琴%张秀香%杨峰
林慶娟%馬秀琴%張秀香%楊峰
림경연%마수금%장수향%양봉
血液透析%血液透析滤过%甲状旁腺素
血液透析%血液透析濾過%甲狀徬腺素
혈액투석%혈액투석려과%갑상방선소
Hemodialysis%Hemodiafiltration%Parathyroid
目的 比较血液透析与血液透析结合不同频率血液滤过(血液透析滤过)的疗效.方法 将116例维持性血液透析患者采用随机数字表法分为3组,分别为对照组(34例)、研究1组(37例)和研究2组(45例).对照组患者每周3次血液透析；研究1组患者每2周5次血液透析、1次血液透析滤过(血液透析:血液透析滤过为5∶1)；研究2组患者每周2次血液透析、1次血液透析滤过(血液透析:血液透析滤过为2∶1).观察透析时并发症发生率、透析前后血尿素氮、肌酐、血磷、甲状旁腺激素(PTH)的水平,计算尿素清除指数(KT/V)和蛋白分解代谢率(PCR).结果 3组患者尿素氮、肌酐、KT/V、PCR差异无统计学意义.其中研究2组和研究1组血磷清除率、PTH清除率优于对照组[分别为(50.5±2.1)％、(32.6±2.7)％比(14.3±4.0)％,(40±4)％、(17±6)％比(11±4)％],差异均有统计学意义(P＜0.05或P＜0.01),研究2组优于研究1组,差异均有统计学意义(P＜0.05或P＜0.01).结论 血液透析与血液透析滤过2∶1的血液净化方式在维持性血液透析患者中能取得较好的透析效果,可提高患者生活质量.
目的 比較血液透析與血液透析結閤不同頻率血液濾過(血液透析濾過)的療效.方法 將116例維持性血液透析患者採用隨機數字錶法分為3組,分彆為對照組(34例)、研究1組(37例)和研究2組(45例).對照組患者每週3次血液透析；研究1組患者每2週5次血液透析、1次血液透析濾過(血液透析:血液透析濾過為5∶1)；研究2組患者每週2次血液透析、1次血液透析濾過(血液透析:血液透析濾過為2∶1).觀察透析時併髮癥髮生率、透析前後血尿素氮、肌酐、血燐、甲狀徬腺激素(PTH)的水平,計算尿素清除指數(KT/V)和蛋白分解代謝率(PCR).結果 3組患者尿素氮、肌酐、KT/V、PCR差異無統計學意義.其中研究2組和研究1組血燐清除率、PTH清除率優于對照組[分彆為(50.5±2.1)％、(32.6±2.7)％比(14.3±4.0)％,(40±4)％、(17±6)％比(11±4)％],差異均有統計學意義(P＜0.05或P＜0.01),研究2組優于研究1組,差異均有統計學意義(P＜0.05或P＜0.01).結論 血液透析與血液透析濾過2∶1的血液淨化方式在維持性血液透析患者中能取得較好的透析效果,可提高患者生活質量.
목적 비교혈액투석여혈액투석결합불동빈솔혈액려과(혈액투석려과)적료효.방법 장116례유지성혈액투석환자채용수궤수자표법분위3조,분별위대조조(34례)、연구1조(37례)화연구2조(45례).대조조환자매주3차혈액투석；연구1조환자매2주5차혈액투석、1차혈액투석려과(혈액투석:혈액투석려과위5∶1)；연구2조환자매주2차혈액투석、1차혈액투석려과(혈액투석:혈액투석려과위2∶1).관찰투석시병발증발생솔、투석전후혈뇨소담、기항、혈린、갑상방선격소(PTH)적수평,계산뇨소청제지수(KT/V)화단백분해대사솔(PCR).결과 3조환자뇨소담、기항、KT/V、PCR차이무통계학의의.기중연구2조화연구1조혈린청제솔、PTH청제솔우우대조조[분별위(50.5±2.1)％、(32.6±2.7)％비(14.3±4.0)％,(40±4)％、(17±6)％비(11±4)％],차이균유통계학의의(P＜0.05혹P＜0.01),연구2조우우연구1조,차이균유통계학의의(P＜0.05혹P＜0.01).결론 혈액투석여혈액투석려과2∶1적혈액정화방식재유지성혈액투석환자중능취득교호적투석효과,가제고환자생활질량.
Objective To compare the complication of sustaining hemodialysis (HD) by different modality of HD:HD combined with hemodiafiltration(HDF) (HD/HDF =5∶1) and HD/HDF 2∶1.Methods The 110 cases were randomly assigned into three groups:HD group (34 cases),HD/HDF 5∶ 1 group (37 cases),HD/HDF 2∶1group(45 cases).The patients of HD group were given hemodialysis three times a week,patients of HD/HDF 5∶1 group were given blood dialysis three times a week and hemodialysis and hemofiltration once every two weeks (hemodialysis:hemodialysis and hemofiltration 5∶1),patients of HD/HDF 2∶1 group were given blood dialysis 2 times a week,once weekly hemodialysis and hemofiltration (blood dialysis:hemodialysis and hemofiltration 2 ∶1).The incidence of complication were observed during treating,and blood nitrogen,creatinine,phosphonium,parathyroid were detected before and after hemodialysis.Results Phosphate removal rate and parathyroid clearance in HD/HDF 2∶1 group,and HD/HDF 5∶1 group were significandy higher than those in HD group [(50.5 ± 2.1)％,(32.6 ±2.7)％ vs (14.3 ±4.0)％,(40±4)％,(17 ±6)％ vs (11 ±4)％,P＜0.05 or P＜0.01],and those in HD/HDF 2∶1 group were also higher than those in HD/HDF 5∶1 group(P ＜0.05 or P ＜0.01).There were no statistically significant differences of blood urea nitrogen,creatinine,KT/V,PCR in three groups of patients.Conclusion Hemodialysis and hemofiltration 2∶1 blood purification in hemodialysis patients is worth promotion.
