中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
9期
1347-1348
,共2页
高血压,妊娠性%TNF-α
高血壓,妊娠性%TNF-α
고혈압,임신성%TNF-α
Hypertension,pregnancy-Induced%TNF-α
目的 研究妊娠高血压患者肿瘤坏死因子-α(TNF-α)表达与肾脏损伤的相关性.方法 选取60例妊娠高血压患者为研究组,同期健康孕妇59例为对照组,检测TNF-α表达及肾功能情况.结果 血肌酐44 ～ 133 μmol/L 59例(正常组),TNF-α值为(10.3±4.1)ng/L；血肌酐133～177 μmol/L 31例(轻度组),TNF-α值(21.7±2.1)μg/L；血肌酐＞177 μmol/L 29例(重度组),TNF-α值(26.9±1.6) μg/L；TNF-α组间比较:重度组与轻度组、轻度组与正常组比较差异均有统计学意义(P＜0.05),且TNF-α的三组表达呈正相关(相关系数=0.32).结论 妊娠高血压患者的血清TNF-α表达水平与肾脏损伤程度呈正相关.
目的 研究妊娠高血壓患者腫瘤壞死因子-α(TNF-α)錶達與腎髒損傷的相關性.方法 選取60例妊娠高血壓患者為研究組,同期健康孕婦59例為對照組,檢測TNF-α錶達及腎功能情況.結果 血肌酐44 ～ 133 μmol/L 59例(正常組),TNF-α值為(10.3±4.1)ng/L；血肌酐133～177 μmol/L 31例(輕度組),TNF-α值(21.7±2.1)μg/L；血肌酐＞177 μmol/L 29例(重度組),TNF-α值(26.9±1.6) μg/L；TNF-α組間比較:重度組與輕度組、輕度組與正常組比較差異均有統計學意義(P＜0.05),且TNF-α的三組錶達呈正相關(相關繫數=0.32).結論 妊娠高血壓患者的血清TNF-α錶達水平與腎髒損傷程度呈正相關.
목적 연구임신고혈압환자종류배사인자-α(TNF-α)표체여신장손상적상관성.방법 선취60례임신고혈압환자위연구조,동기건강잉부59례위대조조,검측TNF-α표체급신공능정황.결과 혈기항44 ～ 133 μmol/L 59례(정상조),TNF-α치위(10.3±4.1)ng/L；혈기항133～177 μmol/L 31례(경도조),TNF-α치(21.7±2.1)μg/L；혈기항＞177 μmol/L 29례(중도조),TNF-α치(26.9±1.6) μg/L；TNF-α조간비교:중도조여경도조、경도조여정상조비교차이균유통계학의의(P＜0.05),차TNF-α적삼조표체정정상관(상관계수=0.32).결론 임신고혈압환자적혈청TNF-α표체수평여신장손상정도정정상관.
Objective To research and analyze the correlation of TNF-αexpression and renal damage in gestational hypertension patients.Methods 60 patients with gestational hypertension were selected as study group.Meanwhile,59 healthy pregnant women were selected as control group.The TNF-α expression and renal function were tested and analyzed.Results The TNF-α expression in study group was (24.7 ± 5.6)μg/L,(12.1 ± 8.2)μg/L in control group (P ＜ 0.05).The serum creatinine in 29 patients in the study group was (317 ± 24) μmol/L,TNF-α (26.9± 1.6)μg/L.The serum creatinine in other 31 patients was (153 ± 18)μmol/L,TNF-α (21.7 ± 2.1)μg/L.The serum creatinine in control group was (56 ± 19) μmol/L,TNF-α (10.3 ±4.1) μg/L.There was a positive correlation between TNF-α expression and serum creatinine.Conclusion The TNF-α expression may be positively correlate with renal damage in gestational hypertension patients.
