CAJ | 학술논문

目的探讨常规血液学检查在孕妇进行地中海贫血(地贫)产前筛查中的作用.方法选择2011年10月至2012年9月在我院接受产前筛查的2443例孕妇作为研究对象.血常规、血清铁和血红蛋白电泳检查作为孕妇的常规产检项目,孕妇的配偶同时作血常规检查,对筛查阳性病例做基因诊断检查.结果血红蛋白电泳检测发现HbA2异常孕妇629例,进一步对其进行基因检测,发现夫妻同表型者59例,夫妻同基因型54例,共确诊地贫胎儿52例(α-地贫24例、β-地贫28例),其中重型地贫胎儿5例(α-地贫2例,β-地贫3例).629例HbA2异常的孕妇红细胞计数(RBC)、血红蛋白(Hb)、红细胞平均体积(MCV)均明显低于正常水平(P＜0.05),红细胞分布宽度(RDW)明显高于正常水平(P＜0.05).结论血常规红细胞参数和血红蛋白电泳等血液学检查在地贫产前筛查中有一定的作用.
목적 탐토상규혈액학검사재잉부진행지중해빈혈(지빈)산전사사중적작용.방법 선택2011년10월지2012년9월재아원접수산전사사적2443례잉부작위연구대상.혈상규、혈청철화혈홍단백전영검사작위잉부적상규산검항목,잉부적배우동시작혈상규검사,대사사양성병례주기인진단검사.결과 혈홍단백전영검측발현HbA2이상잉부629례,진일보대기진행기인검측,발현부처동표형자59례,부처동기인형54례,공학진지빈태인52례(α-지빈24례、β-지빈28례),기중중형지빈태인5례(α-지빈2례,β-지빈3례).629례HbA2이상적잉부홍세포계수(RBC)、혈홍단백(Hb)、홍세포평균체적(MCV)균명현저우정상수평(P＜0.05),홍세포분포관도(RDW)명현고우정상수평(P＜0.05).결론 혈상규홍세포삼수화혈홍단백전영등혈액학검사재지빈산전사사중유일정적작용.
Objective To investigate methods,results and effective of hematological examination in prenatal thalassemia screening in pregnant women.Methods We selected 2443 cases of prenatal screening pregnant women from September 2011 to December 2012 in our hospital as the research object.At present we had blood routine,serum iron and hemoglobin electrophoresis check to pregnant women as conventional production test project,gave pregnant women spouse the blood routine inspection,the screening positive cases were accepted with gene diagnosis inspection.Results Hemoglobin electrophoresis test found 629 cases of HbA2 abnormal,further genetic tests results found that couples with same phenotypic 59 cases,couples with same genotype 54 ones,confirmed 52 thalassemia fetus (α-thalassemia 24 cases,β-thalassemia 28 cases).5 cases of severe thalassemia fetus (α-thalassemia 2 cases,β-thalassemia 3 cases).The RBC,Hb and MCV were all lower than normal levels (P ＜ 0.05).The RBC volume distribution width (RDW) was obviously higher than the normal level (P ＜ 0.05).Conclusion Hematological examination such as blood routine RBC parameters and hemoglobin electrophoresis has certain effect in prenatal thalassemia screening.