中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
27期
5-7
,共3页
儿科学%粒细胞%哮喘%病毒
兒科學%粒細胞%哮喘%病毒
인과학%립세포%효천%병독
Pediatrics%Granulocvtes%Asthma%Viruses
目的 检测病毒相关性喘息患儿血清中嗜酸性粒细胞及其趋化因子的水平,探讨二者在病毒相关性喘息发生、发展中的作用.方法 选择68例病毒相关性喘息患儿作为观察组,另选择42例健康儿童作为对照组,检测并比较观察组急性期和恢复期及对照组儿童外周血嗜酸性粒细胞计数和血清嗜酸性粒细胞趋化因子水平.结果 观察组急性期嗜酸性粒细胞计数为(1.12±0.62)×109/L,恢复期为(0.34±0.13)×109/L,对照组为(0.16±0.07)×109/L,观察组急性期嗜酸性粒细胞计数高于恢复期和对照组,且观察组恢复期高于对照组,差异均有统计学意义(P＜0.05).观察组急性期嗜酸性粒细胞趋化因子水平为(437.2±87.6) ng/L,恢复期为(182.4±56.2) ng/L,对照组为(84.1±39.7) ng/L,观察组急性期嗜酸性粒细胞趋化因子水平高于恢复期和对照组,且观察组恢复期高于对照组,差异均有统计学意义(P＜0.05).观察组急性期、恢复期以及对照组血清嗜酸性粒细胞趋化因子水平与其外周血嗜酸性粒细胞计数呈正相关(r=0.579、0.593、0.581,P＜ 0.05).结论 嗜酸性粒细胞及其趋化因子可能参与了病毒相关性喘息患儿的病理生理过程,二者水平的测定可监测婴幼儿喘息的病程变化,有利于临床诊治.
目的 檢測病毒相關性喘息患兒血清中嗜痠性粒細胞及其趨化因子的水平,探討二者在病毒相關性喘息髮生、髮展中的作用.方法 選擇68例病毒相關性喘息患兒作為觀察組,另選擇42例健康兒童作為對照組,檢測併比較觀察組急性期和恢複期及對照組兒童外週血嗜痠性粒細胞計數和血清嗜痠性粒細胞趨化因子水平.結果 觀察組急性期嗜痠性粒細胞計數為(1.12±0.62)×109/L,恢複期為(0.34±0.13)×109/L,對照組為(0.16±0.07)×109/L,觀察組急性期嗜痠性粒細胞計數高于恢複期和對照組,且觀察組恢複期高于對照組,差異均有統計學意義(P＜0.05).觀察組急性期嗜痠性粒細胞趨化因子水平為(437.2±87.6) ng/L,恢複期為(182.4±56.2) ng/L,對照組為(84.1±39.7) ng/L,觀察組急性期嗜痠性粒細胞趨化因子水平高于恢複期和對照組,且觀察組恢複期高于對照組,差異均有統計學意義(P＜0.05).觀察組急性期、恢複期以及對照組血清嗜痠性粒細胞趨化因子水平與其外週血嗜痠性粒細胞計數呈正相關(r=0.579、0.593、0.581,P＜ 0.05).結論 嗜痠性粒細胞及其趨化因子可能參與瞭病毒相關性喘息患兒的病理生理過程,二者水平的測定可鑑測嬰幼兒喘息的病程變化,有利于臨床診治.
목적 검측병독상관성천식환인혈청중기산성립세포급기추화인자적수평,탐토이자재병독상관성천식발생、발전중적작용.방법 선택68례병독상관성천식환인작위관찰조,령선택42례건강인동작위대조조,검측병비교관찰조급성기화회복기급대조조인동외주혈기산성립세포계수화혈청기산성립세포추화인자수평.결과 관찰조급성기기산성립세포계수위(1.12±0.62)×109/L,회복기위(0.34±0.13)×109/L,대조조위(0.16±0.07)×109/L,관찰조급성기기산성립세포계수고우회복기화대조조,차관찰조회복기고우대조조,차이균유통계학의의(P＜0.05).관찰조급성기기산성립세포추화인자수평위(437.2±87.6) ng/L,회복기위(182.4±56.2) ng/L,대조조위(84.1±39.7) ng/L,관찰조급성기기산성립세포추화인자수평고우회복기화대조조,차관찰조회복기고우대조조,차이균유통계학의의(P＜0.05).관찰조급성기、회복기이급대조조혈청기산성립세포추화인자수평여기외주혈기산성립세포계수정정상관(r=0.579、0.593、0.581,P＜ 0.05).결론 기산성립세포급기추화인자가능삼여료병독상관성천식환인적병리생리과정,이자수평적측정가감측영유인천식적병정변화,유리우림상진치.
Objective To detect the levels of eosinophil and eotaxin in the children with virus associated wheezing diseases,and explore the role of both in virus correlation breathing occurrence and development.Methods Sixty-eight cases of children with virus associated wheezing diseases were selected as observation group,and the other 42 cases of healthy children were selected as control group.The peripheral eosinophil count and serum eotaxin level were detected and compared in observation group and control group on the acute stage and recovery stage.Results The eosinophil count in observation group on the acute stage was (1.12 ± 0.62) × 1099/L,the recovery stage was (0.34 ± 0.13) × 109/L,control group was (0.16 ± 0.07) ×109/L,the eosinophil count in observation group on the acute stage was higher than that on the recovery stage and control group,the eosinophil count in observation group on the recovery stage was higher than that in control group,there were statistically significant differences (P ＜ 0.05).The eotaxin level in observation group on the acute stage was (437.2 ±87.6) ng/L,the recovery stage was (182.4 ±56.2) ng/L,control group was (84.1 ± 39.7) ng/L,the eotaxin level in observation group on the acute stage was higher than that on the recovery stage and control group,the eotaxin level in observation group on the recovery stage was higher than that in control group,there were statistically significant differences (P ＜0.05).There were positively correlated between the eosinophil count and the eotaxin level in observation group on the acute stage,recovery stage and control group (r =0.579,0.593,0.581,P＜ 0.05).Conclusions The eosinophils and eotaxin may be involved in the children with virus associated wheezing diseases pathophysiological process,the levels of the eosinophils and eotaxin can monitor the course change,and be helpful for clinical diagnosis and treatment.
