中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
5期
50-51,56
,共3页
庞一雄%胡磊%黄维江%郑威%廖志敏%李萍
龐一雄%鬍磊%黃維江%鄭威%廖誌敏%李萍
방일웅%호뢰%황유강%정위%료지민%리평
食管肿瘤%WDHD1蛋白
食管腫瘤%WDHD1蛋白
식관종류%WDHD1단백
Esophageal neoplasms%WDHD1 protein
目的 探讨WDHD1蛋白在人食管鳞癌组织中的表达及临床意义.方法 采用免疫组化MaxVision法检测WDHD1蛋白在食管鳞癌、食管腺癌和癌周正常食管组织中的表达.结果 WDHD1蛋白在食管鳞癌组织中的表达(15.68±3.01)明显高于在食管腺癌和正常食管组织中的表达(4.66±2.46,3.89±2.98),差异有统计学意义(t=11.17,21.12,P＜0.05),WDHD1蛋白在食管腺癌组织中的表达与正常食管组织中的表达比较差异无统计学意义(P＞0.05).WDHD1蛋白在食管鳞癌高、中分化组织中的表达高于低分化组织,在TNM分期Ⅲ+Ⅳ期组织中的表达高于Ⅰ+Ⅱ期、在浸润深度T3+T4组织中的表达高于T1 +T2组织,在有淋巴结转移组织中的表达高于无淋巴结转移组织,差异均有统计学意义(P＜0.05).结论 WDHD1蛋白在食管鳞癌中高表达,与食管鳞癌分化程度、恶性程度、浸润深度、淋巴结转移密切有关,在食管鳞癌的发生、发展过程中可能起重要作用.
目的 探討WDHD1蛋白在人食管鱗癌組織中的錶達及臨床意義.方法 採用免疫組化MaxVision法檢測WDHD1蛋白在食管鱗癌、食管腺癌和癌週正常食管組織中的錶達.結果 WDHD1蛋白在食管鱗癌組織中的錶達(15.68±3.01)明顯高于在食管腺癌和正常食管組織中的錶達(4.66±2.46,3.89±2.98),差異有統計學意義(t=11.17,21.12,P＜0.05),WDHD1蛋白在食管腺癌組織中的錶達與正常食管組織中的錶達比較差異無統計學意義(P＞0.05).WDHD1蛋白在食管鱗癌高、中分化組織中的錶達高于低分化組織,在TNM分期Ⅲ+Ⅳ期組織中的錶達高于Ⅰ+Ⅱ期、在浸潤深度T3+T4組織中的錶達高于T1 +T2組織,在有淋巴結轉移組織中的錶達高于無淋巴結轉移組織,差異均有統計學意義(P＜0.05).結論 WDHD1蛋白在食管鱗癌中高錶達,與食管鱗癌分化程度、噁性程度、浸潤深度、淋巴結轉移密切有關,在食管鱗癌的髮生、髮展過程中可能起重要作用.
목적 탐토WDHD1단백재인식관린암조직중적표체급림상의의.방법 채용면역조화MaxVision법검측WDHD1단백재식관린암、식관선암화암주정상식관조직중적표체.결과 WDHD1단백재식관린암조직중적표체(15.68±3.01)명현고우재식관선암화정상식관조직중적표체(4.66±2.46,3.89±2.98),차이유통계학의의(t=11.17,21.12,P＜0.05),WDHD1단백재식관선암조직중적표체여정상식관조직중적표체비교차이무통계학의의(P＞0.05).WDHD1단백재식관린암고、중분화조직중적표체고우저분화조직,재TNM분기Ⅲ+Ⅳ기조직중적표체고우Ⅰ+Ⅱ기、재침윤심도T3+T4조직중적표체고우T1 +T2조직,재유림파결전이조직중적표체고우무림파결전이조직,차이균유통계학의의(P＜0.05).결론 WDHD1단백재식관린암중고표체,여식관린암분화정도、악성정도、침윤심도、림파결전이밀절유관,재식관린암적발생、발전과정중가능기중요작용.
Objective To investigate the clinical significance of WDHD1 protein expression in esophageal squamous cell carcinoma.Methods The expression of WDHD1 protein in esophageal squamous cell carcinoma,adenocarcinoma of esophagus and normal esophagus tissues by immunohistochemical MaxVision was detected.Results The expression of WDHD1 protein in the tissues of esophageal squamous cell carcinoma was significantly higher than that in the normal esophagus tissues and adenocarcinoma of esophagus (15.68 ± 3.01 vs.3.89 ± 2.98 and 4.66 ± 2.46)(P ＜ 0.05),there was no significant between normal esophagus tissues and adenocarcinoma of esophagus (P ＞ 0.05).The expression of WDHD 1 protein in the tissues of esophageal squamous cell carcinoma,high-middle differentiation tissues was higher than poorly differentiation,TNM stage Ⅲ + Ⅳ stage was higher than Ⅰ + Ⅱ stage,depth of invasion T3 + T4 was higher than T1 + T2,with lymph node metastasis tissue was higher than without,differences was statistically significant (P ＜0.05).Conclusions The higher expression of WDHD1 protein is the marker of high invasive and low histological grade of esophageal squamous cell carcinoma,and WDHD1 in esophageal squamous cell carcinomas may play an important role in development.
