CAJ | 학술논문

目的从药物经济学的角度分析和比较三种方案:莫西沙星组、莫西沙星联合氨溴索组、阿奇霉素联合左氧氟沙星组,治疗慢性支气管炎急性发作(AECB)的临床疗效、安全性、依从性及经济效果.方法检索中国期刊全文数据库、万方医学数据库及中文科技期刊全文数据库,纳入三种方案对慢性支气管炎急性发作治疗的随机对照试验(RCT)文献,通过数据的分析来对药物做出经济学评价.结果三种方案的总有效率分别为94.92％、95.08％、94.90％,差异均元统计学意义(P＞0.05),成本效果比分别为213.34、536.40、61.22.结论三种治疗方案疗效相近,阿奇霉素与左氧氟沙星联合使用时具有经济学优势.
목적 종약물경제학적각도분석화비교삼충방안:막서사성조、막서사성연합안추색조、아기매소연합좌양불사성조,치료만성지기관염급성발작(AECB)적림상료효、안전성、의종성급경제효과.방법 검색중국기간전문수거고、만방의학수거고급중문과기기간전문수거고,납입삼충방안대만성지기관염급성발작치료적수궤대조시험(RCT)문헌,통과수거적분석래대약물주출경제학평개.결과 삼충방안적총유효솔분별위94.92％、95.08％、94.90％,차이균원통계학의의(P＞0.05),성본효과비분별위213.34、536.40、61.22.결론 삼충치료방안료효상근,아기매소여좌양불사성연합사용시구유경제학우세.
Objective From the point of view of pharmaceutical economics,to analyze and compare the clinical efficacy,safety,compliance and economic effect of three kinds of scheme:1.moxifloxacin,2.moxifioxacin combined with ambroxol,3.azithromycin combined with levofloxacin in the treatment of acute exacerbation of chronic bronchitis (AECB).Methods Retrieval Chinese joumal full-text database,Wanfang medical database and Chinese science and technology periodical full-text database,included three options for the treatment of AECB randomized controlled trial (RCT) literature,through the analysis of the data to make drug economics evaluation.Results The total effective rates of three programs were 94.92％,95.08％,94.90％,the difference was not statistically significant (P ＞ 0.05).The cost-effectiveness ratios were 213.34,536.40,61.22.Conclusion The efficacy of three treatment options is similar,azithromycin combined with levofloxacin has economic advantages.