CAJ | 학술논문

自噬是一个发生在真核细胞中由细胞初级溶酶体处理内源性底物的一系列生化过程,其主要作用是清除和降解自身受损的细胞器及多余的生物大分子,并利用降解产物提供能量和重建细胞结构,在维持细胞稳态和细胞生命活动等方面起重要作用.近年来,研究发现肾小球足细胞的自噬活性水平与足细胞的损伤和蛋白尿的发生发展有关.自噬在肾小球足细胞中起到的调控作用成为对抗足细胞损伤的研究热点,其中自噬相关基因Beclin-1在自噬调控中的作用更是引起了广泛关注.现就近年来关于Beclin-1在足细胞自噬调控中作用的相关研究进行综述.
자서시일개발생재진핵세포중유세포초급용매체처리내원성저물적일계렬생화과정,기주요작용시청제화강해자신수손적세포기급다여적생물대분자,병이용강해산물제공능량화중건세포결구,재유지세포은태화세포생명활동등방면기중요작용.근년래,연구발현신소구족세포적자서활성수평여족세포적손상화단백뇨적발생발전유관.자서재신소구족세포중기도적조공작용성위대항족세포손상적연구열점,기중자서상관기인Beclin-1재자서조공중적작용경시인기료엄범관주.현취근년래관우Beclin-1재족세포자서조공중작용적상관연구진행종술.
Autophagy is the cytoplasm and organelles of eukaryotic cells through degradation of itself,a " self digest",a series of biochemical process is a kind of programmed cell death,its main function is to remove and degrade its damaged organelles and redundant biological macromolecules,and use the degradation products provide energy,reconstruction and cellular structure,in the steady state of cell and cell life activities play an important role.In recent years,autophagy in glomerular cells play a role of regulation and control have become the focus in the confrontation podocyte damage,including Beclin-1 autophagy related genes in the role of autophagy regulation has caused wide public concern.This article chooses of Beclin-1 in sertoli cell autophagy related research in the role of regulation are reviewed.