CAJ | 학술논문

目的研究分析疏血通与奥拉西坦联用对脑出血患者NIHSS及MMSE评分情况的影响,探索该治疗方式的疗效.方法选择2012年4月至2013年4月在我院治疗的脑出血患者98例作为研究对象.以数字法随机分成观察组(49例)和对照组(49例).对两组患者均常规用药甘露醇和甘油果糖等对症治疗,并辅以康复训练.对照组加用胞磷胆碱钠,观察组则加用疏血通注射液以及奥拉西坦药物注射液治疗,治疗3周后对比两组的NIHSS评分、MMSE评分以及血肿体积及周围低密度区情况,并比较两组不良反应情况.结果观察组治疗3周后NIHSS评分为(2.23±1.96),显著低于治疗前的(7.15±4.68),以及对照组治疗后的(3.91±2.87),差异均有统计学意义(P＜0.05).观察组治疗3周后MMSE评分为(27.08±6.12),显著高于治疗前的(16.32±5.40),以及对照组治疗后的(21.76±5.95),差异均有统计学意义(P＜0.05).治疗后两组的血肿体积以及周围低密度区范围均下降,但观察组治疗后下降幅度较对照组更大,差异均有统计学意义(P＜0.05).两组在不良反应方面对比差异无统计学意义(P＞0.05).结论疏血通联合奥拉西坦治疗脑出血疗效显著,能够明显改善患者神经功能症状,值得临床推荐.
목적 연구분석소혈통여오랍서탄련용대뇌출혈환자NIHSS급MMSE평분정황적영향,탐색해치료방식적료효.방법 선택2012년4월지2013년4월재아원치료적뇌출혈환자98례작위연구대상.이수자법수궤분성관찰조(49례)화대조조(49례).대량조환자균상규용약감로순화감유과당등대증치료,병보이강복훈련.대조조가용포린담감납,관찰조칙가용소혈통주사액이급오랍서탄약물주사액치료,치료3주후대비량조적NIHSS평분、MMSE평분이급혈종체적급주위저밀도구정황,병비교량조불량반응정황.결과 관찰조치료3주후NIHSS평분위(2.23±1.96),현저저우치료전적(7.15±4.68),이급대조조치료후적(3.91±2.87),차이균유통계학의의(P＜0.05).관찰조치료3주후MMSE평분위(27.08±6.12),현저고우치료전적(16.32±5.40),이급대조조치료후적(21.76±5.95),차이균유통계학의의(P＜0.05).치료후량조적혈종체적이급주위저밀도구범위균하강,단관찰조치료후하강폭도교대조조경대,차이균유통계학의의(P＜0.05).량조재불량반응방면대비차이무통계학의의(P＞0.05).결론 소혈통연합오랍서탄치료뇌출혈료효현저,능구명현개선환자신경공능증상,치득림상추천.
Objective To study and analyze the impact of Shuxuetong combined with oxiracetam on the NIHSS and MMSE scores of patients with cerebral hemorrhage,and to explore the efficacy of the treatment.Methods 98 patients with cerebral hemorrhage were chosen from our hospital from April,2012 to April,2013 and were randomly divided into an observation group and a control group,49 cases for each group.All patients received regular medication,such as fructose,mannitol,and glycerol symptomatic treatment and rehabilitation training.In addition,the control group were treated with citicoline sodium,and the observation group with Shuxuetong and oxiracetam.Three weeks after the treatment,the NIHSS and MMSE scores,the hematoma volume,the surrounding low-density district condition,and adverse reactions were compared between the two groups.Results The NIHSS and MMSE scores were (2.23 ± 1.96) and (27.08 ± 6.12) 3 weeks after the treatment and were (7.15 ± 4.68) and (16.32 ± 5.40) before the treatment in the observation group and were (3.91 ± 2.87) and (21.76 ± 5.95) 3 weeks after the treatment in the control group,respectively,with statistical differences (P ＜ 0.05).After the treatment,the hematoma volume and the range of surrounding lowdensity district declined in both groups,but declined more in the observation group than in the control group,with statistical differences (P ＜ 0.05).There were no statistical differences in adverse reactions between the two groups (P ＞ 0.05).Conclusions Shuxuetong combined with oxiracetam in the treatment of cerebral hemorrhage has significant effect,can significantly improve the neurological symptoms,and is worth being clinically recommended.