中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
6期
813-815
,共3页
灯盏细辛注射液%丙二醛%髓过氧化物酶%还原型谷胱甘肽
燈盞細辛註射液%丙二醛%髓過氧化物酶%還原型穀胱甘肽
등잔세신주사액%병이철%수과양화물매%환원형곡광감태
Dengzhanxinxi injection%Malondialdehyde%Medullary peroxidase%Reduced glutathione
目的 探讨灯盏细辛注射液的抗氧化作用 .方法 对比50例门诊患者(存在胸闷、胸痛、头晕、肢体麻木、言语謇涩、中风偏瘫等症状)接受灯盏细辛注射液治疗前后血浆中的丙二醛,髓过氧化物酶和还原型谷胱甘肽浓度的差异.结果 患者静脉滴注灯盏细辛注射液治疗90 min后,血浆丙二醛、髓过氧化物酶明显降低[(1.2 ± 0.3)μmol/L 比(1.5 ± 0.3)μmol/L,P=0.023 5;(200± 48) μg/L 比(223 ±43) μg/L,P=0.013 2],还原型谷胱甘肽浓度升高[(4.3 ± 2.7) μmol/L 比(3.4 ± 1.7) μmol/L,P=0.048 9].结论 灯盏细辛注射液可抑制体内氧自由基,升高还原物质含量,发挥抗氧化作用.
目的 探討燈盞細辛註射液的抗氧化作用 .方法 對比50例門診患者(存在胸悶、胸痛、頭暈、肢體痳木、言語謇澀、中風偏癱等癥狀)接受燈盞細辛註射液治療前後血漿中的丙二醛,髓過氧化物酶和還原型穀胱甘肽濃度的差異.結果 患者靜脈滴註燈盞細辛註射液治療90 min後,血漿丙二醛、髓過氧化物酶明顯降低[(1.2 ± 0.3)μmol/L 比(1.5 ± 0.3)μmol/L,P=0.023 5;(200± 48) μg/L 比(223 ±43) μg/L,P=0.013 2],還原型穀胱甘肽濃度升高[(4.3 ± 2.7) μmol/L 比(3.4 ± 1.7) μmol/L,P=0.048 9].結論 燈盞細辛註射液可抑製體內氧自由基,升高還原物質含量,髮揮抗氧化作用.
목적 탐토등잔세신주사액적항양화작용 .방법 대비50례문진환자(존재흉민、흉통、두훈、지체마목、언어건삽、중풍편탄등증상)접수등잔세신주사액치료전후혈장중적병이철,수과양화물매화환원형곡광감태농도적차이.결과 환자정맥적주등잔세신주사액치료90 min후,혈장병이철、수과양화물매명현강저[(1.2 ± 0.3)μmol/L 비(1.5 ± 0.3)μmol/L,P=0.023 5;(200± 48) μg/L 비(223 ±43) μg/L,P=0.013 2],환원형곡광감태농도승고[(4.3 ± 2.7) μmol/L 비(3.4 ± 1.7) μmol/L,P=0.048 9].결론 등잔세신주사액가억제체내양자유기,승고환원물질함량,발휘항양화작용.
Objective To discuss the antioxidant effect of Dengzhanxinxi injection.Methods This study included 50 outpatients who had chest pain,dizziness,numbness,speech Jian astringent,stroke,paralysis and other symptoms before having fleabane injection treatment.Plasma malondialdehyde,medullary peroxidase (MPO)and reduced glutathione (GSH) concentration were detected.Results After treatment of Dengzhanxinxi injection,plasma malondialdehyde decreased [(1.2 ± 0.3) μmol/L vs (1.5 ± 0.3) μmol/L,P =0.023 5] ; MPO concentration decreased [(200 ±48)μg/L vs (223 ±43)μg/L,P =0.013 2]; the GSH concentrationicreased[(4.3 ±2.7)μmol/L vs (3.4 ±1.7)μmol/L,P=0.048 9].Conclusion Dengzhanxinxi can inhibit oxygen free radicals.
