国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
3期
191-193
,共3页
胆汁酸%2型糖尿病%胆汁酸受体%G蛋白耦联胆汁酸受体5
膽汁痠%2型糖尿病%膽汁痠受體%G蛋白耦聯膽汁痠受體5
담즙산%2형당뇨병%담즙산수체%G단백우련담즙산수체5
Bile acids%Type 2 diabetes mellitus%Farnesoid X receptor%G protein-coupled bile acid receptor 5
研究发现,胆汁酸代谢异常影响胰岛素敏感性和糖代谢.胆汁酸是一种代谢调节器,它通过受体依赖性和非受体依赖性途径发挥信号分子的作用.在受体依赖性途径中,介导胆汁酸信号转导的最重要信号分子是核受体法尼醇X受体(FXR)及膜受体G蛋白耦联胆汁酸受体5(TGR5).胆汁酸的信号通路紊乱会导致胰岛素敏感性降低.因此,对胆汁酸代谢的调节,尤其是对其信号通路的调节有望成为治疗2型糖尿病的潜在方法.
研究髮現,膽汁痠代謝異常影響胰島素敏感性和糖代謝.膽汁痠是一種代謝調節器,它通過受體依賴性和非受體依賴性途徑髮揮信號分子的作用.在受體依賴性途徑中,介導膽汁痠信號轉導的最重要信號分子是覈受體法尼醇X受體(FXR)及膜受體G蛋白耦聯膽汁痠受體5(TGR5).膽汁痠的信號通路紊亂會導緻胰島素敏感性降低.因此,對膽汁痠代謝的調節,尤其是對其信號通路的調節有望成為治療2型糖尿病的潛在方法.
연구발현,담즙산대사이상영향이도소민감성화당대사.담즙산시일충대사조절기,타통과수체의뢰성화비수체의뢰성도경발휘신호분자적작용.재수체의뢰성도경중,개도담즙산신호전도적최중요신호분자시핵수체법니순X수체(FXR)급막수체G단백우련담즙산수체5(TGR5).담즙산적신호통로문란회도치이도소민감성강저.인차,대담즙산대사적조절,우기시대기신호통로적조절유망성위치료2형당뇨병적잠재방법.
Studies show that dysregulation of bile acids could affect insulin sensitivity and glucose metabolism.Bile acids are metabolic regulators that act as signaling molecules through receptor-dependent and -independent pathways.The most prominent signaling molecules mediating bile acid signaling are the nuclear receptor farnesoid X receptor(FXR) and the membrane receptor G protein-coupled bile acid receptor 5 (TGR5).Dysregulation of these pathways might contribute to the reduction of insulin sensitivity.Therefore,the manipulation of bile acid homeostasis,especially the regulation of its signaling pathways might be a potential treatment of type 2 diabetes.
