郑州大学学报(医学版)
鄭州大學學報(醫學版)
정주대학학보(의학판)
JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES)
2013年
1期
112-114
,共3页
孟新%张程达%牛雅萱%刘秀玮%王蒙%张卫东
孟新%張程達%牛雅萱%劉秀瑋%王矇%張衛東
맹신%장정체%우아훤%류수위%왕몽%장위동
乳癌%腋窝淋巴结转移%E-cadherin%CD44V6
乳癌%腋窩淋巴結轉移%E-cadherin%CD44V6
유암%액와림파결전이%E-cadherin%CD44V6
目的:探讨用乳癌组织中E-cadherin和CD44V6的表达水平预测乳癌腋窝淋巴结转移的价值.方法:用免疫组化法检测98例乳癌(浸润性导管癌)患者手术切除标本中E-cadherin和CD44V6的表达情况,以术后病理检查结果为金标准,根据E-cadherin和CD44V6的表达水平预测腋窝淋巴结转移情况,分析单一因素和联合模式预测的灵敏度、特异度、误诊率和漏诊率等指标.结果:E-cadherin单一因素预测腋窝淋巴结转移的灵敏度为60.71%,漏诊率为39.29%,特异度为92.86%,误诊率为7.14%;CD44V6单一因素预测腋窝淋巴结转移的灵敏度为64 29%,漏诊率为35.71%,特异度为61.91%,误诊率为38.10%;E-cadherin和CD44V6串联模式预测的灵敏度为41.07%,漏诊率为58.93%,特异度为95.24%,误诊率为4.76%;E-cadherin和CD44V6并联模式预测的灵敏度为83.93%,漏诊率为16.07%,特异度为59.52%,误诊率为40.48%.结论:E-cadherin单一因素和E-cadherin与CD44V6串联模式预测乳癌淋巴结转移的特异度高,可为腋窝淋巴结清扫术的取舍和术后治疗方案的选择提供帮助;E-cadherin与CD44V6并联能提高淋巴结转移的检出率.
目的:探討用乳癌組織中E-cadherin和CD44V6的錶達水平預測乳癌腋窩淋巴結轉移的價值.方法:用免疫組化法檢測98例乳癌(浸潤性導管癌)患者手術切除標本中E-cadherin和CD44V6的錶達情況,以術後病理檢查結果為金標準,根據E-cadherin和CD44V6的錶達水平預測腋窩淋巴結轉移情況,分析單一因素和聯閤模式預測的靈敏度、特異度、誤診率和漏診率等指標.結果:E-cadherin單一因素預測腋窩淋巴結轉移的靈敏度為60.71%,漏診率為39.29%,特異度為92.86%,誤診率為7.14%;CD44V6單一因素預測腋窩淋巴結轉移的靈敏度為64 29%,漏診率為35.71%,特異度為61.91%,誤診率為38.10%;E-cadherin和CD44V6串聯模式預測的靈敏度為41.07%,漏診率為58.93%,特異度為95.24%,誤診率為4.76%;E-cadherin和CD44V6併聯模式預測的靈敏度為83.93%,漏診率為16.07%,特異度為59.52%,誤診率為40.48%.結論:E-cadherin單一因素和E-cadherin與CD44V6串聯模式預測乳癌淋巴結轉移的特異度高,可為腋窩淋巴結清掃術的取捨和術後治療方案的選擇提供幫助;E-cadherin與CD44V6併聯能提高淋巴結轉移的檢齣率.
목적:탐토용유암조직중E-cadherin화CD44V6적표체수평예측유암액와림파결전이적개치.방법:용면역조화법검측98례유암(침윤성도관암)환자수술절제표본중E-cadherin화CD44V6적표체정황,이술후병리검사결과위금표준,근거E-cadherin화CD44V6적표체수평예측액와림파결전이정황,분석단일인소화연합모식예측적령민도、특이도、오진솔화루진솔등지표.결과:E-cadherin단일인소예측액와림파결전이적령민도위60.71%,루진솔위39.29%,특이도위92.86%,오진솔위7.14%;CD44V6단일인소예측액와림파결전이적령민도위64 29%,루진솔위35.71%,특이도위61.91%,오진솔위38.10%;E-cadherin화CD44V6천련모식예측적령민도위41.07%,루진솔위58.93%,특이도위95.24%,오진솔위4.76%;E-cadherin화CD44V6병련모식예측적령민도위83.93%,루진솔위16.07%,특이도위59.52%,오진솔위40.48%.결론:E-cadherin단일인소화E-cadherin여CD44V6천련모식예측유암림파결전이적특이도고,가위액와림파결청소술적취사화술후치료방안적선택제공방조;E-cadherin여CD44V6병련능제고림파결전이적검출솔.