CAJ | 학술논문

目的探讨继发于颞叶神经节细胞胶质瘤癫痫的临床特点、癫痫灶定位方法、外科治疗及预后.方法回顾性分析2008年9月至2011年9月24例因癫痫行外科治疗并经病理证实为颞叶神经节细胞胶质瘤患者.结果 24例肿瘤均全切除,并在颅内脑电指导下对癫痫灶进行切除,其中4例行选择性杏仁核海马切除,17例行颞叶及海马切除,3例行包括病灶的颞叶皮层切除.随访1～4年,Engle Ⅰ级19例,Ⅱ级5例,病理检查均为节细胞胶质瘤WHO Ⅰ级,未进行放疗,随访肿瘤无复发.结论颞叶神经节细胞胶质瘤可位于颞叶的多个部位,边界不清,颅内脑电可明确癫痫灶切除范围和深度,指导对肿瘤及其周围致痫灶进行全切除,保证术后癫痫疗效.
목적 탐토계발우섭협신경절세포효질류전간적림상특점、전간조정위방법、외과치료급예후.방법 회고성분석2008년9월지2011년9월24례인전간행외과치료병경병리증실위섭협신경절세포효질류환자.결과 24례종류균전절제,병재로내뇌전지도하대전간조진행절제,기중4례행선택성행인핵해마절제,17례행섭협급해마절제,3례행포괄병조적섭협피층절제.수방1～4년,Engle Ⅰ급19례,Ⅱ급5례,병리검사균위절세포효질류WHO Ⅰ급,미진행방료,수방종류무복발.결론 섭협신경절세포효질류가위우섭협적다개부위,변계불청,로내뇌전가명학전간조절제범위화심도,지도대종류급기주위치간조진행전절제,보증술후전간료효.
Objective Summarizes the clinical features,the method of epileptic focus localization,and the surgical treatment and prognosis of secondary epilepsy caused by the temporal lobe ganglilglioma,Methods 24 cases temporal lobe ganglioglioma patients who received surgical treatment for refractory epiclepsy in Tsinghua University Yuquan Hospital,during SEP 2008-SEP 2011 and confirmed by pathology were analysis retrospectively.Results The diagnosis of temporal lobe epilepsy were comfirmed in 24 cases of patients base on the magnetic resonance.All of these 24 patients received operation of resection with ECOG monitoring,and 4 cases received selective amygdal and hippocampus resection.17 cases received anterior temporal lobe and hippocampus resection.3 cases received anterior temporal lobe resection which including lessions.All patients' results were good,they were followed up for 1 year-4years.Engle Ⅰ 19 cases,Ⅱ 5 cases,Gangliogliomas (WHO Ⅰ) were confirmed to all the Specimen by pathological examination,no radiotherapy were done postoperation,the periodic imaging follow-up without recurrence.Conclusions Surgical treatment is the best choise for epilepsy secondary to the temporal lobe gangliogliomas.We could resect the tumor and the epileptogenic zone totally with the help of intracranioelectrodes.