CAJ | 학술논문

骨骼肌占人类体成分的40％～ 50％,是摄取和利用葡萄糖的重要组织,70％的葡萄糖通过胰岛素依赖的方式被骨骼肌摄取;同时骨骼肌也是2型糖尿病患者发生胰岛素抵抗的重要靶组织.现有研究发现,2型糖尿病患者骨骼肌内细胞器发生重构、外膜细胞退化及凋亡、肌膜下线粒体减少、肌细胞内脂质沉积、慢肌纤维与快肌纤维比值降低等,在临床上表现为胰岛素抵抗、骨骼肌萎缩等糖尿病骨骼肌肌病特征.糖尿病骨骼肌病变的发病机制至今不甚明确,自噬可能是主要原因之一.
골격기점인류체성분적40％～ 50％,시섭취화이용포도당적중요조직,70％적포도당통과이도소의뢰적방식피골격기섭취;동시골격기야시2형당뇨병환자발생이도소저항적중요파조직.현유연구발현,2형당뇨병환자골격기내세포기발생중구、외막세포퇴화급조망、기막하선립체감소、기세포내지질침적、만기섬유여쾌기섬유비치강저등,재림상상표현위이도소저항、골격기위축등당뇨병골격기기병특정.당뇨병골격기병변적발병궤제지금불심명학,자서가능시주요원인지일.
Skeletal muscles serving as important organizations of the uptake and utilization of glucose,constitute 40％-50％ of human body composition and account for nearly 70％ glucose under insulinstimulated conditions.Skeletal muscles are also major target tissues of insulin resistance in type 2 diabetic patients.In subjects with diabetes,it appears that the organelles of skeletal muscles reconstruction,degeneration and apoptosis of pericytes,decrease of mitochondria under muscle membrane,lipid deposition in muscle cells as well as the decrease of the ratio of slow-twitch fiber and fast-twitch fiber,which induce insulin resistance,skeletal muscle atrophy and the other abnormalities.However,the exact mechanisms of diabetic myopathy are not clear so far.Autophagy may be one of the primary factors.