CAJ | 학술논문

新生儿急性肾损伤(AKI)的发生率并不低,在缺氧缺血性损伤、感染、肾毒性药物的使用及泌尿道梗阻等情况下均可发生,其中我国以围生期窒息排在病因的首位.近年来由于食品安全问题形势严峻,泌尿道梗阻的发生率也在上升.对于AKI高危儿,儿童卫生保健系统应更加注重此类疾病的预防及筛查.在新生儿AKI人群中,由于血清肌酐及尿液受较多因素影响,波动较大或难以定量计算,使得明确诊断有一定困难,因此关于新生儿AKI早期标志物的研究有极大的临床意义,目前研究热点包括中性粒细胞明胶酶相关脂质运载蛋白及胱抑素C.新生儿AKI的治疗应该注重解决原发疾病如缺氧缺血等,严重病例可考虑肾脏替代治疗,但病死率仍较高,主要与原发疾病严重度及并发症的出现有关.
신생인급성신손상(AKI)적발생솔병불저,재결양결혈성손상、감염、신독성약물적사용급비뇨도경조등정황하균가발생,기중아국이위생기질식배재병인적수위.근년래유우식품안전문제형세엄준,비뇨도경조적발생솔야재상승.대우AKI고위인,인동위생보건계통응경가주중차류질병적예방급사사.재신생인AKI인군중,유우혈청기항급뇨액수교다인소영향,파동교대혹난이정량계산,사득명학진단유일정곤난,인차관우신생인AKI조기표지물적연구유겁대적림상의의,목전연구열점포괄중성립세포명효매상관지질운재단백급광억소C.신생인AKI적치료응해주중해결원발질병여결양결혈등,엄중병례가고필신장체대치료,단병사솔잉교고,주요여원발질병엄중도급병발증적출현유관.
The incidence of acute kidney injury(AKI) in neonate is not low,it occurs in many cases such as ischemic-hypoxic injury,infection,administration of nephrotoxicity drugs and urinary tract obstruction,of which perinatal asphyxia ranked first in China.Due to the severe food security crisis,the occurrence of urinary tract obstruction is rising in recent years.The child health care should pay attention to prevent and screen this kind of disease for the high risk group.The diagnosis of AKI is difficult for newborn because serum creatinine and urine are hard to make a definite boundary.So study of early markers of AKI seems to be of great importance,of which neutrophil gelatinase associated lipocalin and cystatin C are research focuses,treatments should aim at solving primary disease such as ischemic,and so on.Renal replacement therapy is recommended when it comes to severe cases,but mortality still remains high,corresponding to severe primary disease and complications.