CAJ | 학술논문

目的：研究β-catenin/CCN1在肝纤维化患者肝组织中的表达及其在肝纤维化过程中的作用。方法免疫组织化学检测肝纤维化患者及正常对照组肝组织中β-catenin、CCN1、α-SM A 的表达情况。统计学分析β-catenin与CCN1的相关性。结果肝纤维化患者肝组织中β-catenin、CCN1的表达明显增高，主要表达在α-SM A阳性的纤维间隔周围的肝细胞，其中部分肝细胞β-catenin发生入核移位；相关性分析结果显示，肝纤维化患者肝组织中肝细胞表达β-catenin与CCN1呈正相关。结论在肝纤维化的发生过程中，纤维间隔周围肝细胞通过β-catenin上调 CCN1参与肝纤维化的发生发展。
목적：연구β-catenin/CCN1재간섬유화환자간조직중적표체급기재간섬유화과정중적작용。방법면역조직화학검측간섬유화환자급정상대조조간조직중β-catenin、CCN1、α-SM A 적표체정황。통계학분석β-catenin여CCN1적상관성。결과간섬유화환자간조직중β-catenin、CCN1적표체명현증고，주요표체재α-SM A양성적섬유간격주위적간세포，기중부분간세포β-catenin발생입핵이위；상관성분석결과현시，간섬유화환자간조직중간세포표체β-catenin여CCN1정정상관。결론재간섬유화적발생과정중，섬유간격주위간세포통과β-catenin상조 CCN1삼여간섬유화적발생발전。
Objective To study the expression of β-catenin/CCN1 in patients with liver fibrosis and their roles in liver fibrosis .Methods Immunohistochemistry was applied to investigate the expression of β-catenin ,CCN1 andα-SMA in liver tissues with fibrosis and then analysis the relationship between β-catenin and CCN1 .Results The expression ofβ-catenin and CCN1 was significantly higher in patients with liver fibrosis compared with normal controls .Most of the positive cells were hepatocytes around the fibrous septa ,where the α-SMA was positive .More importantly ,β-catenin translocated into nuclear in some hepatocytes . The expression of β-catenin was positively correlated with CCN 1 . Conclusion Upregulation of β-catenin/CCN1 in hepatocytes around , play certain roles in the development of liver fibrosis .