CAJ | 학술논문

目的评价短暂性高原因素对光气中毒兔急性肺损伤的影响.方法新西兰大白兔40只,雌雄不拘,体重2.0～ 2.5 kg,采用随机数字表法,随机分为4组(n=10):对照组(C组);高原因素组(H组)低压低氧2h;光气中毒组(P组)吸入光气3 min;高原光气中毒组(HP组)吸入光气3 rin后低压低氧2h.于中毒前(L)、中毒后(T2)、低压低氧后即刻(T3)、1 h(T4)和6 h(T5)时测定RR及PaO2,计算氧合指数(OI);于T5时取肺组织标本,测定肺水含量(LW)并计算肺系数(LC),光镜下观察肺组织病理学结果.结果与C组比较,H组T3时RR升高,P组及HP组T2-5时RR升高,Ol降低,LW和LC增加(P＜0.05或0.01);与P组比较,HP组T3-5时RR升高,OI降低,LW和LC增加(P＜0.05或0.01),P组及HP组肺组织发生病理性改变,而HP组的程度较重.结论短暂性高原因素可明显加重光气中毒兔急性肺损伤的程度.
목적 평개단잠성고원인소대광기중독토급성폐손상적영향.방법 신서란대백토40지,자웅불구,체중2.0～ 2.5 kg,채용수궤수자표법,수궤분위4조(n=10):대조조(C조);고원인소조(H조)저압저양2h;광기중독조(P조)흡입광기3 min;고원광기중독조(HP조)흡입광기3 rin후저압저양2h.우중독전(L)、중독후(T2)、저압저양후즉각(T3)、1 h(T4)화6 h(T5)시측정RR급PaO2,계산양합지수(OI);우T5시취폐조직표본,측정폐수함량(LW)병계산폐계수(LC),광경하관찰폐조직병이학결과.결과 여C조비교,H조T3시RR승고,P조급HP조T2-5시RR승고,Ol강저,LW화LC증가(P＜0.05혹0.01);여P조비교,HP조T3-5시RR승고,OI강저,LW화LC증가(P＜0.05혹0.01),P조급HP조폐조직발생병이성개변,이HP조적정도교중.결론 단잠성고원인소가명현가중광기중독토급성폐손상적정도.
Objective To investigate the effects of transient plateau factor on acute lung injury induced by phosgene poisoning in rabbits.Methods Forty New Zealand white rabbits of both sexes,aged 2.0-2.5 kg,were randomly divided into 4 groups (n =10 each) using a random number table:control group (group C),plateau factor group (group H),phosgene poisoning group (group P),and phosgene poisoning and plateau factor group (group HP).In group H,the rabbits were exposed to a simulated altitude of 33000 m for 2 h.In group P,the rabbits were exposed to phosgene for 3 min only.In group HP,the rabbits were exposed to phosgene for 33 min and then to a simulated altitude of 3000 m for 2 h.Respiratory rate (RR) was recorded and blood samples were taken before exposure to phosgene (T1),after exposure to phosgene (T2),and at 0,1 and 6 h after onset of exposure to a simulated altitude of 33000 m (T3-5) for determination of PaO2 and oxygenation index (OI) was calculated.The chests were opened at T5 and lungs removed for determination of lung water content (LC) and for microscopic examination.Lung coefficient (LC) was calculated.Results Compared with C group,RR was significantly increased at T3 in group H (P ＜ 0.05),and RR was increased and OI was decreased at T2-5 in P and HP groups (P ＜ 0.05 or 0.01).Compared with P group,RR was increased and OI was decreased at T3-5 in HP group (P ＜ 0.05 or 0.01).LW and LC were significantly higher in P and HP groups than in group C,and in HP group than in group P (P ＜ 0.05 or 0.01).The microscopic examination showed that pathological changes were observed in P and HP groups,however,the changes were severer in HP group.Conclusion Transient plateau factor can obviously aggravate the degree of acute lung injury induced by phosgene poisoning in rabbits.