CAJ | 학술논문

近年研究发现，维生素D缺乏除与骨软化相关外，还与高血压、糖尿病、代谢综合征等多种疾病相关。维生素D在体内经肝脏和肾脏两次羟基化后作用于其受体而发挥生理作用。笔者通过查阅国内外相关文献，介绍维生素D与疾病的关系及维生素D受体基因多态性研究现状，阐述检测维生素D常用方法的优缺点，提出检测维生素D的最佳方法及其受体基因多态性检测的重要性，从而指导临床医生合理用药。
근년연구발현，유생소D결핍제여골연화상관외，환여고혈압、당뇨병、대사종합정등다충질병상관。유생소D재체내경간장화신장량차간기화후작용우기수체이발휘생리작용。필자통과사열국내외상관문헌，개소유생소D여질병적관계급유생소D수체기인다태성연구현상，천술검측유생소D상용방법적우결점，제출검측유생소D적최가방법급기수체기인다태성검측적중요성，종이지도림상의생합리용약。
In recent years , many studies have found that vitamin D insufficiency is associated with osteomalacia , hyperten-sion, diabetes, metabolic syndrome and other diseases .Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, and then in the kidney by a 1α-hydroxylase for the second time to form the active metabolite 1,25-dihydroxy vitamin D ,which binds to the intracellular vitamin D receptor and exerts its effects .This paper reviewed the relationship between vitamin D and disease , present research situation of gene polymorphism of vitamin D receptor , and the advantages and limitations of several methods of vitamin D detection, and proposed the best method for detecting vitamin D receptor gene polymorphism and the importance of the detection state to guide clinicians to use drug rationally .