CAJ | 학술논문

目的：观察并分析恶性脑胶质瘤术后患者放疗前、后99m Tc-HL91 SPECT脑乏氧显像T/N比值的变化差异性及变化趋势,比较单纯术后放疗的Ⅱ级脑胶质细胞瘤患者放疗前后乏氧显像T/N比值差值与放疗后6个月疗效之间的相关性。方法：对35例恶性脑胶质瘤术后患者,分别于放疗前、后进行99m Tc-HL91 SPECT脑乏氧显像检测,测定早期相(0．5小时)及延迟相(5个小时)的肿瘤区与周围正常脑组织放射性计数比值T/N,将检测结果进行差异性比较。筛选出其中13例Ⅱ级脑胶质瘤患者,以RECIST标准对比MRI资料评价放疗疗效,比较放疗前后T/N差值与疗效的相关性。结果：Ⅱ级脑胶质瘤术后患者乏氧显像早期相T/N比值均数值放疗后高于放疗前,差异有统计学意义( p<0．05)。Ⅱ级脑胶质瘤术后患者乏氧显像延迟相T/N比值均数值放疗后低于放疗前,差异有统计学意义( p<0．05)。Ⅲ级及Ⅱ-Ⅳ级脑胶质瘤术后患者乏氧显像延迟相T/N比值均数值放疗后低于放疗前,差异有统计学意义(p<0．05)。Ⅱ级脑胶质细胞瘤放疗前、后99mTc-HL91 SPECT脑乏氧显像延迟相(5小时)T/N比值差值与放疗后6个月疗效呈正相关,有统计学意义(r=0．635,p=0．020)。所有患者检测过程中均无任何严重毒副作用。结论：Ⅱ级恶性脑胶质瘤术后患者放疗前后99m Tc-HL91 SPECT脑乏氧显像适用于短期放疗疗效的评价。
목적：관찰병분석악성뇌효질류술후환자방료전、후99m Tc-HL91 SPECT뇌핍양현상T/N비치적변화차이성급변화추세,비교단순술후방료적Ⅱ급뇌효질세포류환자방료전후핍양현상T/N비치차치여방료후6개월료효지간적상관성。방법：대35례악성뇌효질류술후환자,분별우방료전、후진행99m Tc-HL91 SPECT뇌핍양현상검측,측정조기상(0．5소시)급연지상(5개소시)적종류구여주위정상뇌조직방사성계수비치T/N,장검측결과진행차이성비교。사선출기중13례Ⅱ급뇌효질류환자,이RECIST표준대비MRI자료평개방료료효,비교방료전후T/N차치여료효적상관성。결과：Ⅱ급뇌효질류술후환자핍양현상조기상T/N비치균수치방료후고우방료전,차이유통계학의의( p<0．05)。Ⅱ급뇌효질류술후환자핍양현상연지상T/N비치균수치방료후저우방료전,차이유통계학의의( p<0．05)。Ⅲ급급Ⅱ-Ⅳ급뇌효질류술후환자핍양현상연지상T/N비치균수치방료후저우방료전,차이유통계학의의(p<0．05)。Ⅱ급뇌효질세포류방료전、후99mTc-HL91 SPECT뇌핍양현상연지상(5소시)T/N비치차치여방료후6개월료효정정상관,유통계학의의(r=0．635,p=0．020)。소유환자검측과정중균무임하엄중독부작용。결론：Ⅱ급악성뇌효질류술후환자방료전후99m Tc-HL91 SPECT뇌핍양현상괄용우단기방료료효적평개。
objective:To observe and analyze the change tendency of T/N ratio of 99m Tc-HL91 SPECT lack oxygen imaging before and after radiotherapy for postoperative patients with malignant glioma . For patients with gradeⅡbrain glio-ma who were treated with simple postoperative radiotherapy ,the correlation between the change of T/N ratio before and af-ter radiotherapy and the curative efficacy 6 months after radiotherapy was evaluated. Methods:Thirty-five cases of postop-erative patients with malignant glioma received 99m Tc-HL91 SPECT cerebral lack oxygen imaging examination before and after radiotherapy. The radioactive count ratio T/N of tumor tissue VS. the normal brain tissue around the tumor area in the early phase (0. 5 hour) and delayed phase (5 hours) was detected. The test results were compared. For the 13 patients with grade Ⅱ glioma, the efficacy of radiotherapy was evaluated according to the results of the MRI with RECIST stand-ards. The correlation between the variation of T/N before and after radiotherapy and the radiotherapy efficacy was studied. Results: The early phase T/N ratio of lack oxygen postoperative imaging of grade Ⅱ glioma patients was significantly higher after radiotherapy than that before radio-therapy (p<0. 05), while the late phase T/N ratio was lower after radiotherapy than that before radiotherapy ( p<0. 05 ) . T/N ratio in delayed phase of levelsⅢandⅡ-Ⅳpostoper-ative patients with glioma after radiotherapy were lower than that before radiotherapy with significant difference ( p <0. 05) . For postoperative patients with grade Ⅱmalignant glioma , the changing of T/N ratio in delayed phase before and after radiotherapy was positively correlated with the radiotherapy curative efficacy after 6 months (r=0. 635,p=0. 020). No serious side effects were observed during the whole process of testing. Conclusion:For patients with grade II brain glio-ma, 99m Tc-HL91 SPECT cerebral lack oxygen imaging examination may be helpful for the evaluation of the short-term radi-ation curative efficacy.