CAJ | 학술논문

探讨姜黄素(Curcumin，简称Cur)对重离子辐射损伤小鼠睾丸组织的防护作用。小鼠灌胃不同剂量的Cur后给予4 Gy剂量12 C6+离子束全身单次照射。24 h后对小鼠睾丸组织形态学变化进行观察，并测定丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性和过氧化氢酶(CAT)活性。结果显示：中、高浓度Cur预处理组对小鼠睾丸组织的形态具有较好的保护作用；低、中浓度Cur预处理组MDA含量显著降低(P<0.05)；与单纯照射组相比，低浓度Cur预处理组SOD活性水平和中浓度Cur预处理组CAT活性水平显著提高(P <0.05)。结果表明：Cur对重离子全身辐射小鼠的抗氧化系统有一定的激活效应，对辐射损伤有一定的防护作用，其机制可能与Cur清除自由基，保护脂质和蛋白质有关。
탐토강황소(Curcumin，간칭Cur)대중리자복사손상소서고환조직적방호작용。소서관위불동제량적Cur후급여4 Gy제량12 C6+리자속전신단차조사。24 h후대소서고환조직형태학변화진행관찰，병측정병이철(MDA)함량、초양화물기화매(SOD)활성화과양화경매(CAT)활성。결과현시：중、고농도Cur예처리조대소서고환조직적형태구유교호적보호작용；저、중농도Cur예처리조MDA함량현저강저(P<0.05)；여단순조사조상비，저농도Cur예처리조SOD활성수평화중농도Cur예처리조CAT활성수평현저제고(P <0.05)。결과표명：Cur대중리자전신복사소서적항양화계통유일정적격활효응，대복사손상유일정적방호작용，기궤제가능여Cur청제자유기，보호지질화단백질유관。
The protective effect of Curcumin (Cur) against the irradiation damage of testis in mice induced by 12C6+ ion beams was studied. Male Kung-Ming mice were exposed to whole body uniformly irradiated with 12C6+ion beams at 4 Gy after pretreated with Cur of different concentration. Then histological alterations were observed. Moreover, malonaldehyde (MDA) level, superoxide dismutase (SOD) activity and catalase (CAT) activity were also measured at 24 h after irradiation. The result showed that middle and high dose Cur pretreated have a good protective effect. Compared with irradiated group, MDA level decreased dramatically in the group of pretreatment with low and middle dose Cur (P <0.05). On the contrary, SOD activity in the pretreated group with low dose Cur significantly increased (P<0.05). Similarly, CAT activity in the pretreated group with middle dose Cur significantly increased (P<0.05). Data suggested that Cur could activate antioxidant system of testis in mice induced by12C6+ion beams, it have some protective effect to radiation damage. The mechanism may involve in its scavenging reactive oxidant species and then protecting lipid and protein capability.