中国眼耳鼻喉科杂志
中國眼耳鼻喉科雜誌
중국안이비후과잡지
CHINESE JOURNAL OF OPHTHALMOLOGY AND OTOLARYNGOLOGY
2014年
5期
278-282
,共5页
孔祥梅%吴彦婵%陈君毅%孙兴怀
孔祥梅%吳彥嬋%陳君毅%孫興懷
공상매%오언선%진군의%손흥부
青光眼%垂直向杯盘比%危险因素%近视%性别%年龄
青光眼%垂直嚮杯盤比%危險因素%近視%性彆%年齡
청광안%수직향배반비%위험인소%근시%성별%년령
Glaucoma%Vertical cup-to-disc ratio%Risk factor%Myopia%Gender%Age
目的:分析眼底杯盘比>0.3人群的临床特点,并探讨原发性开角型青光眼( POAG)的危险因素。方法本研究为一项基于医院的研究,研究对象为临床发现垂直向杯盘比( VCDR)>0.3的人群,经过傅里叶相干光断层扫描( OCT)、视野和其他临床检查后,被判断为正常、青光眼可疑或POAG。将该3组作为因变量,性别、年龄、屈光度、VCDR等因素作为自变量,用logistic回归分析这些因素与POAG的关系,并用危险度(OR)和95%可信限(CI)加以表示。结果共有5137名受试者入选,其中2828(55.05%)为正常,1525(29.69%)为青光眼可疑,784(15.26%)被确诊为POAG;正常组、青光眼可疑组、POAG组VCDR的中位数分别为0.5、0.6、0.8。多元回归分析显示:男性(OR=1.484,95% CI:1.323~1.667),年龄(OR=1.207,95%CI:1.128~1.291每增加20岁),近视(OR=1.369,95%CI:1.298-1.493),VCDR (OR=1.765,95%CI:1.698~1.834每增加0.1)是罹患青光眼的危险因素。结论男性、老龄(尤其是>60岁)、近视(尤其是中高度近视)以及大VCDR是POAG发生的危险因素,VCDR>0.6的人群患青光眼的风险大大增加,应着重筛查。(中国眼耳鼻喉科杂志,2014,14:278-282)
目的:分析眼底杯盤比>0.3人群的臨床特點,併探討原髮性開角型青光眼( POAG)的危險因素。方法本研究為一項基于醫院的研究,研究對象為臨床髮現垂直嚮杯盤比( VCDR)>0.3的人群,經過傅裏葉相榦光斷層掃描( OCT)、視野和其他臨床檢查後,被判斷為正常、青光眼可疑或POAG。將該3組作為因變量,性彆、年齡、屈光度、VCDR等因素作為自變量,用logistic迴歸分析這些因素與POAG的關繫,併用危險度(OR)和95%可信限(CI)加以錶示。結果共有5137名受試者入選,其中2828(55.05%)為正常,1525(29.69%)為青光眼可疑,784(15.26%)被確診為POAG;正常組、青光眼可疑組、POAG組VCDR的中位數分彆為0.5、0.6、0.8。多元迴歸分析顯示:男性(OR=1.484,95% CI:1.323~1.667),年齡(OR=1.207,95%CI:1.128~1.291每增加20歲),近視(OR=1.369,95%CI:1.298-1.493),VCDR (OR=1.765,95%CI:1.698~1.834每增加0.1)是罹患青光眼的危險因素。結論男性、老齡(尤其是>60歲)、近視(尤其是中高度近視)以及大VCDR是POAG髮生的危險因素,VCDR>0.6的人群患青光眼的風險大大增加,應著重篩查。(中國眼耳鼻喉科雜誌,2014,14:278-282)
목적:분석안저배반비>0.3인군적림상특점,병탐토원발성개각형청광안( POAG)적위험인소。방법본연구위일항기우의원적연구,연구대상위림상발현수직향배반비( VCDR)>0.3적인군,경과부리협상간광단층소묘( OCT)、시야화기타림상검사후,피판단위정상、청광안가의혹POAG。장해3조작위인변량,성별、년령、굴광도、VCDR등인소작위자변량,용logistic회귀분석저사인소여POAG적관계,병용위험도(OR)화95%가신한(CI)가이표시。결과공유5137명수시자입선,기중2828(55.05%)위정상,1525(29.69%)위청광안가의,784(15.26%)피학진위POAG;정상조、청광안가의조、POAG조VCDR적중위수분별위0.5、0.6、0.8。다원회귀분석현시:남성(OR=1.484,95% CI:1.323~1.667),년령(OR=1.207,95%CI:1.128~1.291매증가20세),근시(OR=1.369,95%CI:1.298-1.493),VCDR (OR=1.765,95%CI:1.698~1.834매증가0.1)시리환청광안적위험인소。결론남성、노령(우기시>60세)、근시(우기시중고도근시)이급대VCDR시POAG발생적위험인소,VCDR>0.6적인군환청광안적풍험대대증가,응착중사사。(중국안이비후과잡지,2014,14:278-282)
Objective To investigate the clinical characteristics of Chinese subjects with vertical cup -to-disc ratio (VCDR) larger than 0.3 and to evaluate the risk factors for primary open-angle glaucoma (POAG).Methods A cross-sectional, hospital-based study of subjects from Shanghai , China with VCDR of more than 0.3 was conducted.After fourier-domain optical coherence tomography ( FD-OCT) and other clinical examinations were done , the subjects were diagnosed as normal , glaucoma-suspect or POAG.The age, gender, refraction and VCDR in each subgroup were analyzed.Multivariate logistic regression analysis was performed to identify the factors associated with POAG and the data was shown in odds ratio (OR) and 95%confidence interval (CI).Results In total, 5 137 subjects were enrolled in this study.Among them, 2 828 (55.05%) were normal, 1 525 (29.69%) were glaucoma-suspect, and 784 (15.26%) were POAG.The median values of VCDR in the three subgroups were 0.5, 0.6 and 0.8 respectively. Multivariate logistic regression analysis demonstrated that male gender (OR=1.484, 95%CI:1.323~1.667), older age (OR=1.207, 95%CI:1.128~1.291 per 20-year increase), myopia (OR=1.369, 95% CI:1.298~1.493), and VCDR (OR=1.765, 95% CI:1.698 ~1.834 per 0.1 increase) were associated with an increased risk of POAG. Conclusions The risk for glaucoma was largely increased in subjects with VCDR larger than 0.6.Male gender, older age ( especially age greater than 60 years ) , myopia ( especially moderate and high myopia ) , and together with larger VCDR, are risk factors for POAG.