CAJ | 학술논문

目的：探讨雌激素受体XbaⅠ、PvuⅡ基因多态性与四川汉族女性乳腺癌患病风险的关系。方法：采用病例对照研究设计,序贯收集乳腺癌病例221例,健康对照252例。采用问卷调查收集一般人口学特征、身高、体重、生殖生育史、雌激素药物服用史等信息；采用限制性片段长度多态性技术,检测ERα基因XbaⅠ( rs9340799) A/G(x/X)、PvuⅡ(rs2234693)C/T(P/p)基因突变情况。采用非条件多因素Logistic回归模型分析XbaⅠ、PvuⅡ基因多态性的独立效应及联合效应。按绝经状态进行亚组分析。结果：在总人群及不同绝经状态亚组中,XbaⅠ、PvuⅡ基因型分布与乳腺癌患病风险无统计学关联( P>0．05)。以xxPP野生基因型组合做参照,在总人群中,只携带X等位基因能明显降低乳腺癌患病风险(OR=0．31,95%CI：0．11~0．90),该效应与X、p等位基因联合暴露效应接近(OR=0．39,95%CI：0．15~1．00)。在绝经前女性中,上述暴露组合效应分别为0．12(0．03~0．54)和0．25(0．07~0．89)。结论：雌激素受体 XbaⅠX等位基因可能对乳腺癌患病风险具有保护效应。
목적：탐토자격소수체XbaⅠ、PvuⅡ기인다태성여사천한족녀성유선암환병풍험적관계。방법：채용병례대조연구설계,서관수집유선암병례221례,건강대조252례。채용문권조사수집일반인구학특정、신고、체중、생식생육사、자격소약물복용사등신식；채용한제성편단장도다태성기술,검측ERα기인XbaⅠ( rs9340799) A/G(x/X)、PvuⅡ(rs2234693)C/T(P/p)기인돌변정황。채용비조건다인소Logistic회귀모형분석XbaⅠ、PvuⅡ기인다태성적독립효응급연합효응。안절경상태진행아조분석。결과：재총인군급불동절경상태아조중,XbaⅠ、PvuⅡ기인형분포여유선암환병풍험무통계학관련( P>0．05)。이xxPP야생기인형조합주삼조,재총인군중,지휴대X등위기인능명현강저유선암환병풍험(OR=0．31,95%CI：0．11~0．90),해효응여X、p등위기인연합폭로효응접근(OR=0．39,95%CI：0．15~1．00)。재절경전녀성중,상술폭로조합효응분별위0．12(0．03~0．54)화0．25(0．07~0．89)。결론：자격소수체 XbaⅠX등위기인가능대유선암환병풍험구유보호효응。
Objective: To explore the association between XbaⅠand PvuⅡgene polymorphism of ERαand breast cancer risk among females in Sichuan province. Methods: A case-control study was designed. A total of 221 cases of breast cancer and 252 controls were sequentially collected. Questionnaires were used to obtain the factors including demo-graphic characteristics, height, weight, history of reproduction, and estrogen taking history. Restricted fragment length pol-ymorphisms were used to examine XbaⅠ(rs9340799) A/G (x/X), PvuⅡ(rs2234693) C/T (P/p) of ERα. Uncondi-tional logistic regression model was used to evaluate the single and combined effects of XbaⅠ, PvuⅡ gene polymorphism on breast cancer risk. Subgroup analysis on menopausal status was also performed. Results: Significantly association be-tween XbaⅠ, PvuⅡ gene polymorphism and breast cancer was observed among neither total group nor subgroups ( P>0. 05). Conferring to xxPP genotype carriers, for general females, carrying X mutate alleles had lower breast cancer risk (OR=0. 31,95%CI:0. 11-0. 90),which was closed to the effect of co-exposure of X and p allele (OR=0. 39,95%CI:0. 15-1. 00). In premenopausal women, the effect of the exposure modalities above were 0. 12(0. 03-0. 54)and 0. 25 (0. 07-0. 89) respectively. Conclusions:Carrying X allele of XbaⅠmay decrease the risk of breast cancer.